Citation: Liang Meng, Xie Zongbo, Ai Feng, Le Zhanggao. Synthesis of Quinoline Derivatives Catalyzed by α-Chymotrypsin[J]. Chinese Journal of Organic Chemistry, ;2016, 36(11): 2704-2708. doi: 10.6023/cjoc201604051 shu

Synthesis of Quinoline Derivatives Catalyzed by α-Chymotrypsin

Liang Meng ^b ,
Xie Zongbo ^a,b,*,, ,
Ai Feng ^b ,
Le Zhanggao ^a,b,*,,

a.
Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013
b.
Department of Applied Chemistry, East China University of Technology, Nanchang 330013

Corresponding author: Xie Zongbo, zbxie@ecit.cn Le Zhanggao, zhgle@ecit.cn
Received Date: 24 April 2016
Revised Date: 2 June 2016

Fund Project: the National Natural Science Foundation of China 21262002the National Natural Science Foundation of China 21462001the National Natural Science Foundation of China 21465002the Natural Science Foundation of Jiangxi Province 20142BAB203008the Program for Changjiang Scholars and Innovative Research Team in University IRT13054

The α-chymotrypsin-catalyzed Friedländer condensation reaction between 2-aminoaryl ketone and α-methylene ketone was firstly reported, and a series of quinoline derivatives were obtained in moderate to excellent yields. This method is easy to operate and the reaction condition is mild, which not only expands the application of the promiscuity of protease, but also has positive significance for promoting the development of the green chemistry.
- α-chymotrypsin,
- Friedländer condensation,
- quinoline derivatives,
- biocatalysis
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