Citation: Xu Shuying, Chen Xiaojia, Li Jihui, Xu Wenrong, Zhang Yucang. Recent Advances in Transition Metal-Catalyzed Synthesis of Guanidines[J]. Chinese Journal of Organic Chemistry, ;2016, 36(9): 1985-1993. doi: 10.6023/cjoc201604036 shu

Recent Advances in Transition Metal-Catalyzed Synthesis of Guanidines

Xu Shuying ^a ,
Chen Xiaojia ^b ,
Li Jihui ^a,*,, ,
Xu Wenrong ^a ,
Zhang Yucang ^a,*,,

a.
College of Materials and Chemical Engineering, Hainan University, Haikou 570228
b.
Products Quality Supervision and Testing Institute of Hainan Province, Haikou 570003

Corresponding author: Li Jihui, lijihui@hainu.edu.cn Zhang Yucang, zhangyucang88@163.com
Received Date: 18 April 2016
Revised Date: 16 May 2016

Fund Project: the Natural Science Fundation of Hainan Province 20162015the Hainan Province International Science and Technology Specific KJHZ2014-02the Research Fund for the Doctoral Program of Higher Education of China 20134601110004the Natural Science Fundation of Hainan Province 20152027

Figures(9)

Guanidines are a unique class of tri-nitrogen compounds having various bioactivities, which are wildly presented in natural products and drug molecules, and they are wildly used in pharmacy and pesticide fields. Moreover, they have high application value in organic synthesis and functional materials. The synthesis of guanidines has received much attention due to their unique structures and widespread application value. Recently, lots of new synthetic methods of guanidines, especially the synthetic methods based on highly efficient transition metal-catalyzed reactions, have been developed. The recent progress in transition metal-catalyzed reactions developed for the synthesis of guanidines in the past twenty years is summarized. The synthetic methods for various guanidines are introduced comprehensively, and the characteristics and disadvantages of these methods are also discussed, thus it may be helpful for the research on transition metal-catalyzed synthesis of guanidines.
- transition metal-catalyzed,
- C-N formation reaction,
- guanidines,
- synthetic method
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