Citation: Zhao Yuying, Wang Erbing, Wang Yingli. Tetra-butyl Ammonium Iodide-Catalyzed Oxidative Dehydrogenation for the Selective Synthesis of Z-β-Acylamino Enones[J]. Chinese Journal of Organic Chemistry, ;2016, 36(7): 1681-1685. doi: 10.6023/cjoc201601034 shu

Tetra-butyl Ammonium Iodide-Catalyzed Oxidative Dehydrogenation for the Selective Synthesis of Z-β-Acylamino Enones

a.
Institute of Chemical and Biological Technology, Taiyuan University of Science and Technology, Taiyuan 030021
b.
Department of Traditional Chinese Pharmacology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024

Corresponding author: Zhao Yuying,
Received Date: 27 January 2016
Revised Date: 26 February 2016

Fund Project: the Science and Technology Key Project of Shanxi Province 20130313015-2

A tetra-butyl ammonium iodide (TBAI)-catalyzed oxidative dehydrogenation of β-acylamino ketones for the synthesis of Z-β-acylamino enones has been developed. The present method has some distinct advantages such as mild conditions, high selectivity, readily available starting materials, and broad substrate scope. This method is also the first example of oxidative dehydrogenation with the use of TBAI/TBHP (tert-butyl hydroperoxide) oxidation system.
- iodide,
- catalytic dehydrogenation,
- β-acylamino enones,
- stereoselectivity
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