Citation: Xu Guangcan, Liu Qingchuan, Yuan Jie, Hu Zhanxing, Ma Fangfang, Liang Guangyi, Xu Bixue. Synthesis and Anti-Hepatitis B Virus Activities of Galactopyranosyl Derivatives of Matijin-Su[J]. Chinese Journal of Organic Chemistry, ;2016, 36(7): 1617-1625. doi: 10.6023/cjoc201512051 shu

Synthesis and Anti-Hepatitis B Virus Activities of Galactopyranosyl Derivatives of Matijin-Su

Xu Guangcan ^a,c ,
Liu Qingchuan ^b ,
Yuan Jie ^a,d ,
Hu Zhanxing ^a ,
Ma Fangfang ^a,c ,
Liang Guangyi ^a,c,*,, ,
Xu Bixue ^a,*,,

a.
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002
b.
302 Hospital of PLA, Beijing 100039
c.
Guiyang College of Traditional Chinese Medicine, Guiyang 550002
d.
College of Pharmacy, Guizhou University, Guiyang 550002)

Corresponding author: Liang Guangyi, guangyi_liang@126.com Xu Bixue, bixue_xu@126.com
Received Date: 31 December 2015
Revised Date: 10 March 2016

Fund Project: the Western Light Talent Culture Project (2014) AAAAthe National Natural Science Foundation of China No. 81360472

Figures(6)

To improve the concentration in liver lesion tissue and increase the anti-hepatitis B virus (HBV) activities of Matijin-Su (MTS) derivatives, five hepatic targeting galactopyranosyl derivatives of MTS were synthesized by indirect connecting the liver targeting galactose ligands to MTS using ethanolamin as a linker and their structures were confirmed by ¹H NMR, ¹³CNMR, ¹H-¹H COSY, HMQC and ESI-MS. The anti-HBV activities of those compounds were evaluated in HepG2 2.2.15 cells. The screening results showed that all target compounds had inhibitory effect on HBV DNA replication in HepG2 2.2.15 cells in a dose-response manner.
- hepatic targeting,
- derivatives of Matijin-Su,
- glacatose,
- anti-hepatitis B virus activity
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