Citation: Zhang Yingpeng, You Caixia, Yang Yunshang, Liu Xiaoyu, Guo Huichen, Dong Yuying. Synthesis of Reversible Fluorescence Quenched Probe for Cu²⁺ and Imaging in PK-15 cells[J]. Chinese Journal of Organic Chemistry, ;2016, 36(6): 1401-1406. doi: 10.6023/cjoc201512033 shu

Synthesis of Reversible Fluorescence Quenched Probe for Cu²⁺ and Imaging in PK-15 cells

Zhang Yingpeng ^a,*,, ,
You Caixia ^a ,
Yang Yunshang ^a,*,, ,
Liu Xiaoyu ^a ,
Guo Huichen ^b ,
Dong Yuying ^a

a.
School of Petrochemical Engineering, Lanzhou University of Technology, Lanzhou 730050
b.
Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730050

Corresponding author: Zhang Yingpeng, yingpengzhang@126.com Yang Yunshang, yangyunshang@tom.com
Received Date: 23 December 2015
Revised Date: 15 January 2016

Fund Project: Project supported by the Natural Science Foundation of Gansu Province No. 2014GS03265

Figures(8)

A new pyrazoline derivative 1-(2-hydroxyphenyl)-4-(9-anthryl)-3-benzothiazole pyrazolin (P1) was designed and synthesized. The recognition properties of the target compound P1 with metal ions had been investigated by UV absorption and fluorescence spectrophotometry. The probe exhibits several favorable features, including instantaneous, reversible recognition, high sensitivity and selectivity to copper ions. Cytotoxicity test and fluorescent immunoassay results show that compound P1 has good biocompatibility and low toxicity with its IC₅₀value of 376.558 μmol/L.
- pyrazoline,
- fluorescent probe,
- copper ions,
- recognition,
- PK-15 living cells
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沈阳化工大学材料科学与工程学院沈阳 110142

Synthesis of Reversible Fluorescence Quenched Probe for Cu2+ and Imaging in PK-15 cells

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通讯作者: 陈斌, bchen63@163.com

Synthesis of Reversible Fluorescence Quenched Probe for Cu²⁺ and Imaging in PK-15 cells