Citation: Shi Yujun, Li Yang, Fang Yuan, Ye Linyu, Chen Jia, Dai Hong. Synthesis and Bioactivity of Novel Cyanoacrylate Derivatives Containing Fluoride Methyl Pyrazole Moiety[J]. Chinese Journal of Organic Chemistry, ;2016, 36(6): 1431-1437. doi: 10.6023/cjoc201512019 shu

Synthesis and Bioactivity of Novel Cyanoacrylate Derivatives Containing Fluoride Methyl Pyrazole Moiety

Shi Yujun ^a,b,*,, ,
Li Yang ^a ,
Fang Yuan ^a ,
Ye Linyu ^b ,
Chen Jia ^b ,
Dai Hong ^b,*,,

a.
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003
b.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019

Corresponding author: Shi Yujun, yjshi2015@163.com Dai Hong, daihong_2001@aliyun.com
Received Date: 14 December 2015
Revised Date: 7 January 2016

Fund Project: Project supported by the National Natural Science Foundation of China Nos.21202089,21372135the Research Foundation of the Six People Peak of Jiangsu Province Nos. 2011-SWYY-009, 2013-SWYY-013and the Science and Technology Project Fund of Nantong City Nos.AS2014011,CP12013002

Figures(1)

In order to find novel cyanoacrylate lead compounds, 17 new cyanoacrylate compounds bearing fluoride methyl pyrazole moiety were synthesized by the method of active substructure combination. They were structurally confirmed by ¹H NMR, ¹³C NMR and elemental analysis. The structures of compounds 7b, 7f, 7j and 7o were also tested through MS technique. Preliminary bioassay data showed that some of the target compounds displayed important anti-tumor activities.
- fluoride methyl pyrazole,
- cyanoacrylate,
- synthesis,
- biological activity
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