Citation: Yang Taiqun, Dai Shan, Qin Cuifang, Huang Kehan, Chen Yuting, Pan Haifeng, Zhang Sanjun, Zhang Kun, Xu Jianhua. Selective Detection of Homocysteine by Using Poly Methyl Vinyl Ether-alt-Maleic Silver Clusters[J]. Chinese Journal of Organic Chemistry, ;2016, 36(4): 867-871. doi: 10.6023/cjoc201511023 shu

Selective Detection of Homocysteine by Using Poly Methyl Vinyl Ether-alt-Maleic Silver Clusters

Yang Taiqun ^a,b ,
Dai Shan ^a ,
Qin Cuifang ^a ,
Huang Kehan ^a ,
Chen Yuting ^a ,
Pan Haifeng ^a ,
Zhang Sanjun ^a,c,, ,
Zhang Kun ^b ,
Xu Jianhua ^a,c

a.
a. State Key Laboratory of Precision Spectroscopy, East China. Normal University, Shanghai 200062;
b.
b. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry East China. Normal University, Shanghai 200062;
c.
c. Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006

Corresponding author: Zhang Sanjun,
Received Date: 13 November 2015
Available Online: 3 December 2015
Fund Project: 上海市自然科学基金(No.15ZR1410100) (No.15ZR1410100)国家自然科学基金(No.61178085)资助项目. (No.61178085)

We report selective detection of homocysteine (Hcy) through luminescent poly methyl vinyl ether-alt-maleic acid (PMVEM) silver nanoclusters (Ag NCs), which were synthesized using PMVEM as scaffold. The as-developed PMVEM-Ag NCs have two emission peaks at 460 and 540 nm. After Hcy was added, the thiol moiety of Hcy can efficiently coordinate on Ag NCs, resulting in luminescence quenching of the 460 and 540 nm peaks. However, the ratio of these two emission peak was linearly correlated with the Hcy concentration from 5 to 100 μmol/L. The detection limits was 1 μmol/L. The detection of Hcy used the ratio of the two emission peaks, which permit selective detection of Hcy and quantitive determination of Hcy levels.
- homocysteine,
- poly methyl vinyl ether-alt-maleic acid,
- fluorescent sensor,
- silver nanoclusters
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