Citation: Zhu Shuai, Xu Lubin, Wang Liang, Xiao Jian. Recent Advances in Asymmetric Synthesis of Optically Active Indole Derivatives from 3-Indolylmethanols[J]. Chinese Journal of Organic Chemistry, ;2016, 36(6): 1229-1240. doi: 10.6023/cjoc201510024 shu

Recent Advances in Asymmetric Synthesis of Optically Active Indole Derivatives from 3-Indolylmethanols

Zhu Shuai ^b ,
Xu Lubin ^b ,
Wang Liang ^a,b,*,, ,
Xiao Jian ^a,b,*,,

a.
aHubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology, Jingmen 448000
b.
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109

Corresponding author: Wang Liang, chemjianxiao@163.com Xiao Jian, chemjianxiao@163.com
Received Date: 21 October 2015
Revised Date: 15 December 2015

Fund Project: the Talents of High Level Scientific Research Foundation of Qingdao Agricultural University Nos.6631112323,6631115015Project supported by the Open Project Program of Hubei Key Laboratory of Drug Synthesis and Optimization Jingchu University of Technology Nos.OPP2015YB01,OPP2015ZD02

Figures(20)

The electrophilic intermediate, vinylogous imine or vinylogous iminium, can be in situ generated from 3-indolyl- methanols under acidic conditions. With the aid of chiral catalysts, miscellaneous nucleophiles can attack these electrophilic intermediates to afford enantioenriched and biologically important 3-substituted indole derivatives. The recent advances of preparation of optically active indole derivatives from 3-indolylmethanols via asymmetric alkylation, asymmetric reduction and asymmetric rearrangement are summarized.
- 3-indolylmethanol,
- optically active,
- indole derivatives,
- asymmetric synthesis
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