Citation: Wang Fengliang, Xu Ling, Chu Guochao, Shi Jing, Guo Qingxiang. Efficient Synthesis of Liraglutide by Using Oxyma as Coupling Reagent[J]. Chinese Journal of Organic Chemistry, ;2015, 36(1): 218-221. doi: 10.6023/cjoc201505014 shu

Efficient Synthesis of Liraglutide by Using Oxyma as Coupling Reagent

1.
Department of Chemistry, University of Science and Technology of China, Hefei 230026

Corresponding author: Shi Jing, shijing@ustc.edu.cn Guo Qingxiang, qxguo@ustc.edu.cn
Received Date: 8 May 2015
Revised Date: 3 August 2015

Fund Project: National Natural Science Foundation of China 21272223National Natural Science Foundation of China 21572214

Figures(5)

As a newly efficient reagent, Oxyma [ethyl 2-cyano-2-(hydroxyimino)acetate] has a lower rate of racemization and relative higher coupling efficiency as compared with HOBt, HOAt, etc. In this work, as an important polypeptide drug for the treatment of diabetes, liraglutide was firstly chemically synthesized with high efficiency by solid chemical synthesis using Oxyma as coupling reagent. The strategy presented here provides an efficient strategy for the chemical synthesis of liraglutide with enlarged scales.
- oxyma,
- liraglutide,
- polypeptide drug,
- solid poly-peptide synthesis
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沈阳化工大学材料科学与工程学院沈阳 110142