Citation: Xu Yanglei, Meng Zheyi, Zhai Jin. pH and Calcium Cooperative Regulation Nanofluidic Gating Device[J]. Acta Chimica Sinica, ;2016, 74(6): 538-544. doi: 10.6023/A16010053 shu

pH and Calcium Cooperative Regulation Nanofluidic Gating Device

1.
Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing 100191

Corresponding author: Zhai Jin, zhaijin@buaa.edu.cn
Received Date: 25 January 2016

Fund Project: the National Basic Research Program of China 2012CB720904the National Natural Science Foundation of China 21271016

Figures(8)

In living body, Ca²⁺-responsive ion channels play crucial roles in many biological activities. Inspired by nature, the design and fabrication of artificial smart nanochannels system become a very significant research subject, mimicking the biological Ca²⁺-responsive signals in ion channels. In this article, by using track-etched artificial polyethylene terephthalate (PET) multiporous membrane materials and modifying intelligent molecules O-Phospho-L-tyrosine (OPLT) through chemical modification method, we demonstrate a new biomimetic artificial smart responsive ion channel system, which presents the cooperative response to pH and calcium. The nanosystem shows ion selective transport, ion gating and ion rectification property, which is similar to the property of biological Ca²⁺-responsive ion channels. And the cooperative responsive property of pH and calcium in OPLT modified nanochannels was also investigated by measuring the current-voltage (I-V) curves. At a low pH value, the surface charge of the nanochannels walls is positive as a result of the amino group (NH₃⁺) of OPLT, the nanosystem attracts the anions and inhibits the cations due to electrostatic interactions between the anions passing through the nanochannels and the nanochannels cations walls, resulting in ion current rectification property. Meanwhile, after adding calcium to the nanosystem, no significant changes of ion current are found. The system presents no calcium responsive property. At a high pH value, the surface charge of the nanochannels walls is negative due to the phosphate group (HPO₄^2-) of OPLT, the nanosystem shows cations-selective. After adding calcium to the solution, the bonding of phosphate group (HPO₄^2-) with calcium (Ca²⁺) results in the neutralization of the surface charge in the nanochannels. This nanochannels switch the polarity of ion transport from cation-selective to non-selective, and turn from the highly conductive state to the low conductive state. The significant decline of the ion current can be observed. Thus, the OPLT modified nanofluidic gating device displays the cooperative effect of pH and calcium. This system provides a new idea for the multiple signal induced ion gating in conical nanochannel devices.
- calcium gating,
- ion channels,
- rectification,
- pH response,
- nanofluidic
1. [1]
  Clapham, D. E. Cell 2007, 131, 1047. doi: 10.1016/j.cell.2007.11.028
2. [2]
  Matulef, K.; Zagotta, W. N. Annu. Rev. Cell Dev. Biol. 2003, 19, 23. doi: 10.1146/annurev.cellbio.19.110701.154854
3. [3]
  Liao, J.; Li, H.; Zeng, W. Z.; Sauer, D. B.; Belmares, R.; Jiang, Y. X. Science 2012, 335, 686. doi: 10.1126/science.1215759
4. [4]
  Berridge, M. J.; Bootman, M. D.; Roderick, H. L. Nat. Rev. Mol. Cell Biol. 2003, 4, 517.
5. [5]
  Methfessel, C.; Boheim, G. Biophys. Struct. Mech. 1982, 9, 35. doi: 10.1007/BF00536014
6. [6]
  Saimi, Y.; Kung, C. Annu. Rev. Physiol. 2002, 64, 289. doi: 10.1146/annurev.physiol.64.100301.111649
7. [7]
  Eismann, E.; Muller, F.; Heinemann, S. H.; Kaupp, U. B. Proc. Natl. Acad. Sci. U. S. A. 1994, 91, 1109. doi: 10.1073/pnas.91.3.1109
8. [8]
  McNally, B.; Somasundaram, A.; Yamashita, M.; Prakriya, M. Nature 2012, 482, 241.
9. [9]
  Ali, M.; Nasir, S.; Ramirez, P.; Cervera, J.; Mafe, S.; Ensinger, W. ACS Nano 2012, 6, 9247. doi: 10.1021/nn303669g
10. [10]
  Siwy, Z. S.; Powell, M. R.; Petrov, A.; Kalman, E.; Trautmann, C.; Eisenberg, R. S. Nano Lett. 2006, 6, 1729. doi: 10.1021/nl061114x
11. [11]
  Deniaud, A.; Rossi, C.; Berquand, A.; Homand, J.; Campagna, S.; Knoll, W.; Brenner, C.; Chopineau, J. Langmuir 2007, 23, 3898. doi: 10.1021/la063105+
12. [12]
  Siwy, Z. S.; Powell, M. R.; Kalman, E.; Astumian, R. D.; Eisenberg, R. S. Nano Lett. 2006, 6, 473. doi: 10.1021/nl0524290
13. [13]
  Vilozny, B.; Actis, P.; Seger, R. A.; Vallmajo-Martin, Q.; Pourmand, N. Anal. Chem. 2011, 83, 6121. doi: 10.1021/ac201322v
14. [14]
  He, Y.; Gillespie, D.; Boda, D.; Vlassiouk, I.; Eisenberg, R.; Siwy, Z. S. J. Am. Chem. Soc. 2009, 131, 5194. doi: 10.1021/ja808717u
15. [15]
  García-Gimenez, E.; Alcaraz, A.; Aguilella, V. M.; Ramírez, P. J. Membr. Sci. 2009, 331, 137. doi: 10.1016/j.memsci.2009.01.026
16. [16]
  Powell, M. R.; Sullivan, M.; Vlassiouk, I.; Constantin, D.; Sudre, O.; Martens, C. C.; Eisenberg, R. S.; Siwy, Z. S. Nat. Nanotechnol. 2008, 3, 51. doi: 10.1038/nnano.2007.420
17. [17]
  Hou, X.; Guo, W.; Jiang, L. Chem. Soc. Rev. 2011, 40, 2385. doi: 10.1039/c0cs00053a
18. [18]
  Regonda, S.; Tian, R.; Gao, J.; Greene, S.; Ding, J.; Hu, W. Biosens. Bioelectron. 2013, 45, 245. doi: 10.1016/j.bios.2013.01.027
19. [19]
  Tian, Y.; Jiang, L. Sci. China Chem. 2011, 54, 603.
20. [20]
  Xiao, K.; Xie, G. H.; Li, P.; Liu, Q.; Hou, G. L.; Zhang, Z.; Ma, J.; Tian, Y.; Wen, L. P.; Jiang, L. Adv. Mater. 2014, 26, 6560. doi: 10.1002/adma.v26.38
21. [21]
  Hou, X.; Guo, W.; Nie, F. Q.; Dong, H.; Tian, Y.; Wen, L. P.; Wang, L.; Cao, L. X.; Yang, Y.; Xue, J. M.; Song, Y. L.; Wang, Y. G.; Liu, D. S.; Jiang, L. J. Am. Chem. Soc. 2009, 131, 7800. doi: 10.1021/ja901574c
22. [22]
  Xie, G. H.; Xiao, K.; Zhang, Z.; Kong, X. Y.; Liu, Q.; Li, P.; Wen, L. P.; Jiang, L. Angew. Chem., Int. Ed. 2015, 54, 13664.
23. [23]
  Gao, J.; Guo, W.; Feng, D.; Wang, H. T.; Zhao, D. Y.; Jiang, L. J. Am. Chem. Soc. 2014, 136, 12265. doi: 10.1021/ja503692z
24. [24]
  Hou, X.; Jiang, L. Physics 2011, 40, 304.
25. [25]
  Guo, W.; Jiang, L. Sci. Sin. Chim. 2011, 41, 1257. doi: 10.1360/032011-186
26. [26]
  Zhou, D.; Meng, Z. Y.; Zhang, M. H.; Zhai, J. Acta Chim. Sinica 2015, 73, 716. doi: 10.6023/A15030217
27. [27]
  Meng, Z. Y.; Bao, H.; Wang, J. T.; Jiang, C. D.; Zhang, M. H.; Zhai, J.; Jiang, L. Adv. Mater. 2014, 26, 2329. doi: 10.1002/adma.v26.15
28. [28]
  Xu, Y. L.; Sui, X.; Guan, S.; Zhai, J.; Gao, L. C. Adv. Mater. 2015, 27, 1851. doi: 10.1002/adma.v27.11
29. [29]
  Xu, Y. L.; Zhang, M. H.; Tian, T.; Shang, Y.; Meng, Z. Y.; Jiang, J. Q.; Zhai, J.; Wang, Y. NPG Asia Mater. 2015, 7, e215. doi: 10.1038/am.2015.98
30. [30]
  Zhang, W. J.; Meng, Z. Y.; Zhai, J.; Heng, L. P. Chem. Commun. 2014, 50, 3552. doi: 10.1039/c3cc47999d
31. [31]
  Apel, P. Y.; Korchev, Y. E.; Siwy, Z.; Spohr, R.; Yoshida, M. Nucl. Instrum. Methods Phys. Res., Sect. B 2001, 184, 337. doi: 10.1016/S0168-583X(01)00722-4
32. [32]
  Siwy, Z.; Fulinski, A. Phys. Rev. Lett. 2002, 89, 198103. doi: 10.1103/PhysRevLett.89.198103
33. [33]
  Hou, X.; Zhang, H. C.; Jiang, L. Angew. Chem., Int. Ed. 2012, 51, 5296.
34. [34]
  Siwy, Z. S. Adv. Funct. Mater. 2006, 16, 735. doi: 10.1002/(ISSN)1616-3028
35. [35]
  Hou, X.; Dong, H.; Zhu, D. B.; Jiang, L. Small 2010, 6, 361. doi: 10.1002/smll.v6:3
1. [1]
  Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
2. [2]
  Jun Huang , Pengfei Nie , Yongchao Lu , Jiayang Li , Yiwen Wang , Jianyun Liu . 丝光沸石负载自支撑氮掺杂多孔碳纳米纤维电容器及高效选择性去除硬度离子. Acta Physico-Chimica Sinica, 2025, 41(7): 100066-0. doi: 10.1016/j.actphy.2025.100066
3. [3]
  Li'na ZHONG , Jingling CHEN , Qinghua ZHAO . Synthesis of multi-responsive carbon quantum dots from green carbon sources for detection of iron ions and L-ascorbic acid. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 709-718. doi: 10.11862/CJIC.20240280
4. [4]
  Zeyu Liu , Wenze Huang , Yang Xiao , Jundong Zhang , Weijin Kong , Peng Wu , Chenzi Zhao , Aibing Chen , Qiang Zhang . Nanocomposite Current Collectors for Anode-Free All-Solid-State Lithium Batteries. Acta Physico-Chimica Sinica, 2024, 40(3): 2305040-0. doi: 10.3866/PKU.WHXB202305040
5. [5]
  Rui Li , Huan Liu , Yinan Jiao , Shengjian Qin , Jie Meng , Jiayu Song , Rongrong Yan , Hang Su , Hengbin Chen , Zixuan Shang , Jinjin Zhao . Emerging Irreversible and Reversible Ion Migrations in Perovskites. Acta Physico-Chimica Sinica, 2024, 40(11): 2311011-0. doi: 10.3866/PKU.WHXB202311011
6. [6]
  Peiran ZHAO , Yuqian LIU , Cheng HE , Chunying DUAN . A functionalized Eu³⁺ metal-organic framework for selective fluorescent detection of pyrene. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 713-724. doi: 10.11862/CJIC.20230355
7. [7]
  Zhongrui Wang , Yuwen Meng , Xu Wang . 双层水凝胶的制备及其pH响应变形实验. University Chemistry, 2025, 40(8): 255-264. doi: 10.12461/PKU.DXHX202410038
8. [8]
  Yameen Ahmed , Xiangxiang Feng , Yuanji Gao , Yang Ding , Caoyu Long , Mustafa Haider , Hengyue Li , Zhuan Li , Shicheng Huang , Makhsud I. Saidaminov , Junliang Yang . Interface Modification by Ionic Liquid for Efficient and Stable FAPbI₃ Perovskite Solar Cells. Acta Physico-Chimica Sinica, 2024, 40(6): 2303057-0. doi: 10.3866/PKU.WHXB202303057
9. [9]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370
10. [10]
  Qingtang ZHANG , Xiaoyu WU , Zheng WANG , Xiaomei WANG . Performance of nano Li₂FeSiO₄/C cathode material co-doped by potassium and chlorine ions. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1689-1696. doi: 10.11862/CJIC.20240115
11. [11]
  Qi Li , Pingan Li , Zetong Liu , Jiahui Zhang , Hao Zhang , Weilai Yu , Xianluo Hu . Fabricating Micro/Nanostructured Separators and Electrode Materials by Coaxial Electrospinning for Lithium-Ion Batteries: From Fundamentals to Applications. Acta Physico-Chimica Sinica, 2024, 40(10): 2311030-0. doi: 10.3866/PKU.WHXB202311030
12. [12]
  Lin LI , Le CHEN , Lingjie HOU , Jiaqi JING , Jiayu DING , Tao ZHOU , Ruiping ZHANG . Smartphone-assisted fluorescent silver nanoclusters as ratiometric sensor for visual colorimetric detection of sulfide. Chinese Journal of Inorganic Chemistry, 2025, 41(11): 2261-2271. doi: 10.11862/CJIC.20250130
13. [13]
  Mengmeng SUN , Rui JIANG , Tianyi ZHAO , Jimin YANG . Fabrication of carboxyl-modified UiO-67 nanomaterials and their highly efficient removal mechanism of anionic dye. Chinese Journal of Inorganic Chemistry, 2026, 42(3): 499-506. doi: 10.11862/CJIC.20250281
14. [14]
  Xiaojing Tian , Zhichun Huang , Qingsong Zhang , Xu Wang , Ning Yang , Nanping Deng . PNIPAm Thermo-Responsive Nanofibers Mats: Morphological Stability and Response Behavior under Cross-Linking. Acta Physico-Chimica Sinica, 2024, 40(4): 2304037-0. doi: 10.3866/PKU.WHXB202304037
15. [15]
  Zhenming Xu , Mingbo Zheng , Zhenhui Liu , Duo Chen , Qingsheng Liu . Experimental Design of Project-Driven Teaching in Computational Materials Science: First-Principles Calculations of the LiFePO₄ Cathode Material for Lithium-Ion Batteries. University Chemistry, 2024, 39(4): 140-148. doi: 10.3866/PKU.DXHX202307022
16. [16]
  Pengyang FAN , Shan FAN , Qinjin DAI , Xiaoying ZHENG , Wei DONG , Mengxue WANG , Xiaoxiao HUANG , Yong ZHANG . Preparation and performance of rich 1T-MoS₂ nanosheets for high-performance aqueous zinc ion battery cathode materials. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 675-682. doi: 10.11862/CJIC.20240339
17. [17]
  Ying Li , Yushen Zhao , Kai Chen , Xu Liu , Tingfeng Yi , Li-Feng Chen . Rational Design of Cross-Linked N-Doped C-Sn Nanofibers as Free-Standing Electrodes towards High-Performance Li-Ion Battery Anodes. Acta Physico-Chimica Sinica, 2024, 40(3): 2305007-0. doi: 10.3866/PKU.WHXB202305007
18. [18]
  Chaolin Mi , Yuying Qin , Xinli Huang , Yijie Luo , Zhiwei Zhang , Chengxiang Wang , Yuanchang Shi , Longwei Yin , Rutao Wang . Galvanic Replacement Synthesis of Graphene Coupled Amorphous Antimony Nanoparticles for High-Performance Sodium-Ion Capacitor. Acta Physico-Chimica Sinica, 2024, 40(5): 2306011-0. doi: 10.3866/PKU.WHXB202306011
19. [19]
  Kezhen Qi , Bei Cheng , Kaiqiang Xu . Ultrafast interfacial charge transfer promoted by the LSPR of Au nanoparticles for photocatalytic H₂ evolution. Acta Physico-Chimica Sinica, 2026, 42(3): 100205-0. doi: 10.1016/j.actphy.2025.100205
20. [20]
  Zhiming Feng , Lili Wu , Chengming Wang . Doubly Oxidized Carbene. University Chemistry, 2025, 40(9): 326-331. doi: 10.12461/PKU.DXHX202411008

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(2112)
HTML views(314)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142