Citation: QIN Yi, SHI Pei, GUAN Quan-Yin, SHI Xia, ZHAO Guo-Liang. A Copper(Ⅱ) Complex Constructed by 2-Phenyl-4-selenazole Carboxylic Acid：Synthesis, Crystal Structure and Biological Activity[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(9): 2013-2020. doi: 10.3969/j.issn.1001-4861.2013.00.266 shu

A Copper(Ⅱ) Complex Constructed by 2-Phenyl-4-selenazole Carboxylic Acid：Synthesis, Crystal Structure and Biological Activity

QIN Yi ¹ ,
SHI Pei ² ,
GUAN Quan-Yin ² ,
SHI Xia ² ,
ZHAO Guo-Liang ^1,2

1.
1 Zhejiang Normal University Xingzhi College, Jinhua, Zhejiang 321004, China;

Received Date: 16 November 2012
Available Online: 1 March 2013
Fund Project: 浙江省自然科学基金(No.Y4080256)资助项目。 (No.Y4080256)

A copper(Ⅱ) complex[Cu₂(NO₃)₂L(phen)₂(H₂O)]NO₃, (HL=2-phenyl-4-selenazole carboxylic acid, phen=1,10-phenanthroline), was synthesized and characterized by elemental analysis and IR spectra. Its crystal structure was determined by single crystal X-ray diffraction method. The complex, C₃₄H₂₄N₈Cu₂O₁₂Se, crystallized in the triclinic system, space group P1. The interaction of the complex with DNA was studied by ethidium bromide (EB) fluorescence spectroscopy. The antibacterial activities of the ligand and the complex against five species of bacteria, Escherichia coli (E. coli), Staphylococcus epidermidis (S. epidermidis), Streptococcus viridans (S. viridans), Staphylococcus aureus (S. aureus) and Acinetobacter baumanii (A. baumanii), were tested respectively. The anticancer activities of the ligand and the complex against human pancreatic cancer line PANC-28 and human hepatocarcinoma line HuH7 were also studied by employing MTT assay. The results revealed that the complex possessed significant biological activity. CCDC: 804066.
- copper(Ⅱ) complex;2-phenyl-4-selenazole carboxylic acid;1,10-phenanthroline;crystal structure;biological activity
1. [1]
  [1] XU Bin-He(徐兵河), SUN Yan(孙燕). Chinese J. New Drugs (Zhongguo Xinyao Zazhi), 1998,7(3):176-180
2. [2]
  [2] Lucia L, Viera V, Jela B. Toxicology, 2006,227(1/2):1-14
3. [3]
  [3] Lovell M A, Xiong S, Lyubartseva G, et al. Free Radic. Biol. Med., 2009,46(11):1527-1533
4. [4]
  [4] Srivastava P C, Robins R K. J. Med. Chem., 1983,26(3):445-448
5. [5]
  [5] Boritzki T J, Berry D A, Besserer J A, et al. Biochem. Pharmacol., 1985,34(7):1109-1114
6. [6]
  [6] Kumar Y, Green R, Borysko K Z, et al. J. Med. Chem., 1993, 36(3):3843-3848
7. [7]
  [7] Kumar Y, Green R, Wise D S, et al. J. Med. Chem., 1993,36 (3):3849-3852
8. [8]
  [8] Erkkilia K E, Odom D T, Barton J K. Chem. Rev., 1999,99 (9):2777-2796
9. [9]
  [9] Peng B, Chao H, Sun B, et al. J. Inorg. Biochem., 2007,101 (3):404-411
10. [10]
  [10] Jiang Q, Xiao N, Shi P F, et al. Coord. Chem. Rev., 2007, 251(15/16):1951-1972
11. [11]
  [11] YAO Wei(姚威), WU Bao-Yan(吴宝燕), GAO Li-Hua (高丽华), et al. Acta Phys.-Chim. Sin. (Wuli Huaxue Xuebao), 2007,23(02):237-241
12. [12]
  [12] GAO En-Jun(高恩君), DING Li-Na(丁丽娜), LIU Qi-Tao (刘祁涛), et al. Acta Phys.-Chim. Sin. (Wuli Huaxue Xuebao). 2005,21(10):1091-1095
13. [13]
  [13] Sigman D S. Acc. Chem. Res., 1986,19(6):180-186
14. [14]
  [14] Thomas A M, Nethaji M, Chakravarty A R. J. Inorg. Biochem., 2004,98(6):1087-1094
15. [15]
  [15] Reddy P A N, Santra B K, Nethaji M, et al. J. Inorg. Biochem., 2004,98(2):377-386
16. [16]
  [16] Ruiz E, Tang X J, Li Y J, et al. J. Cryst. Spectr. Res., 1993, 23(10):791-794
17. [17]
  [17] Muir M M, Gomez G M, Cadiz M E, et al. Inorg. Chim. Acta, 1990,168(1):47-57
18. [18]
  [18] Barkigia K M, Renner M W, Senge M O, et al. J. Phys. Chem. B, 2004,108(7):2173-2180
19. [19]
  [19] Zhou A J, Zheng S L, Fang Y, et al. Inorg. Chem., 2005,44 (13):4457-4459
20. [20]
  [20] Tan C K, Wang J, Leng J D, et al. Eur. J. Inorg. Chem., 2008(5):771-778
21. [21]
  [21] ZHAO Guo-Liang(赵国良), SHI Xia(施霞), ZHANG Jun-Ping(张均平), et al. Scientia Sinica: Chimica(Zhongguo Kexue: Chemistry), 2010,40(10):1525-1535
22. [22]
  [22] ZHAO Guo-Liang(赵国良), SHEN Jin-Bei(沈金杯), SHI Xia (施霞), et al. Chinese J. Inorg. Chem. (Wuji Huaxue Xuebao), 2012,28(5):959-964
23. [23]
  [23] Kamal A, Mallareddy A, Suresh P, et al. Eur. J. Med. Chem., 2012,47:530545
24. [24]
  [24] Sheldrick G M. SADABS, Program for Empirical Absorption Correction of Area detector Data, University of Göttingen, Germany, 1997.
25. [25]
  [25] Sheldrick G M. SHELXS-97, Program for Crystal Structure Solution. University of Göttingen, Germany, 1997.
26. [26]
  [26] Sheldrick G M. SHELXL-97, Program for Crystal Structure Refinement. University of Göttingen, Germany, 1997.
27. [27]
  [27] Gao H L, Yi L, Zhao B, et al. Inorg. Chem., 2006,45(15): 5980-5988
28. [28]
  [28] Singh U P, Tyagi S, Sharma C L, et al. J. Chem. Soc., Dalton Trans., 2002,23:4464-4470
29. [29]
  [29] Nakamoto K(中本一雄), Translated by HUANG De-Ru (黄德如), WANG Ren-Qing(汪仁庆). Infrared and Raman Spectra of Inorganic and Coordination Compounds. 3rd Ed. (无机和配位化合物的红外和拉曼光谱. 3版). Beijing: Chemical Industry Press, 1986.
30. [30]
  [30] Casellato U, Tamburini S, Tomasin P, et al. Inorg. Chim. Acta, 1997,262(2):117-121
31. [31]
  [31] Min D W, Cho B Y, Lee S W. Inorg. Chim. Acta, 2006,359 (2)577-584
32. [32]
  [32] Bünzli J C G, Charbonnière L J, Ziessel R F. J. Chem. Soc., Dalton Trans., 2000,12:1917-1923
33. [33]
  [33] Hubrich M, Peukert M, Seichter W, et al. Polyhedron, 2010, 29(7):1854-1862
34. [34]
  [34] Lakowicz J R, Weber G. Biochemistry, 1973,12(21):4161-4170
35. [35]
  [35] Liu J, Zhang T X, Lu T B, et al. J. Inorg. Biochem., 2002,91(1):269-276
36. [36]
  [36] Baguley B C, Bret M L. Biochemistry, 1984,23(5):937-943
1. [1]
  Xin MA , Ya SUN , Na SUN , Qian KANG , Jiajia ZHANG , Ruitao ZHU , Xiaoli GAO . A Tb₂ complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1347-1356. doi: 10.11862/CJIC.20230357
2. [2]
  Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two Ln^Ⅲ₃ complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188
3. [3]
  Changqing MIAO , Fengjiao CHEN , Wenyu LI , Shujie WEI , Yuqing YAO , Keyi WANG , Ni WANG , Xiaoyan XIN , Ming FANG . Crystal structures, DNA action, and antibacterial activities of three tetranuclear lanthanide-based complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2455-2465. doi: 10.11862/CJIC.20240192
4. [4]
  Jing WU , Puzhen HUI , Huilin ZHENG , Pingchuan YUAN , Chunfei WANG , Hui WANG , Xiaoxia GU . Synthesis, crystal structures, and antitumor activities of transition metal complexes incorporating a naphthol-aldehyde Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2422-2428. doi: 10.11862/CJIC.20240278
5. [5]
  Xinting XIONG , Zhiqiang XIONG , Panlei XIAO , Xuliang NIE , Xiuying SONG , Xiuguang YI . Synthesis, crystal structures, Hirshfeld surface analysis, and antifungal activity of two complexes Na(Ⅰ)/Cd(Ⅱ) assembled by 5-bromo-2-hydroxybenzoic acid ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1661-1670. doi: 10.11862/CJIC.20240145
6. [6]
  Jingjing QING , Fan HE , Zhihui LIU , Shuaipeng HOU , Ya LIU , Yifan JIANG , Mengting TAN , Lifang HE , Fuxing ZHANG , Xiaoming ZHU . Synthesis, structure, and anticancer activity of two complexes of dimethylglyoxime organotin. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1301-1308. doi: 10.11862/CJIC.20240003
7. [7]
  Yingchun ZHANG , Yiwei SHI , Ruijie YANG , Xin WANG , Zhiguo SONG , Min WANG . Dual ligands manganese complexes based on benzene sulfonic acid and 2, 2′-bipyridine: Structure and catalytic properties and mechanism in Mannich reaction. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1501-1510. doi: 10.11862/CJIC.20240078
8. [8]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173
9. [9]
  Xiaoling LUO , Pintian ZOU , Xiaoyan WANG , Zheng LIU , Xiangfei KONG , Qun TANG , Sheng WANG . Synthesis, crystal structures, and properties of lanthanide metal-organic frameworks based on 2, 5-dibromoterephthalic acid ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1143-1150. doi: 10.11862/CJIC.20230271
10. [10]
  Yan Liu , Yuexiang Zhu , Luhua Lai . Introduction to Blended and Small-Class Teaching in Structural Chemistry: Exploring the Structure and Properties of Crystals. University Chemistry, 2024, 39(3): 1-4. doi: 10.3866/PKU.DXHX202306084
11. [11]
  Weina Wang , Fengyi Liu , Wenliang Wang . “Extracting Commonality, Delving into Typicals, Deriving Individuality”: Constructing a Knowledge Graph of Crystal Structures. University Chemistry, 2024, 39(3): 36-42. doi: 10.3866/PKU.DXHX202308029
12. [12]
  Junqiao Zhuo , Xinchen Huang , Qi Wang . Symbol Representation of the Packing-Filling Model of the Crystal Structure and Its Application. University Chemistry, 2024, 39(3): 70-77. doi: 10.3866/PKU.DXHX202311100
13. [13]
  Wenyan Dan , Weijie Li , Xiaogang Wang . The Technical Analysis of Visual Software ShelXle for Refinement of Small Molecular Crystal Structure. University Chemistry, 2024, 39(3): 63-69. doi: 10.3866/PKU.DXHX202302060
14. [14]
  Linjie ZHU , Xufeng LIU . Electrocatalytic hydrogen evolution performance of tetra-iron complexes with bridging diphosphine ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 321-328. doi: 10.11862/CJIC.20240207
15. [15]
  Jinfeng Chu , Lan Jin , Yu-Fei Song . Exploration and Practice of Flipped Classroom in Inorganic Chemistry Experiment: a Case Study on the Preparation of Inorganic Crystalline Compounds. University Chemistry, 2024, 39(2): 248-254. doi: 10.3866/PKU.DXHX202308016
16. [16]
  Liyang ZHANG , Dongdong YANG , Ning LI , Yuanyu YANG , Qi MA . Crystal structures, luminescent properties and Hirshfeld surface analyses of three cadmium(Ⅱ) complexes based on 2-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)benzoate. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1943-1952. doi: 10.11862/CJIC.20240079
17. [17]
  Zhaoyang WANG , Chun YANG , Yaoyao Song , Na HAN , Xiaomeng LIU , Qinglun WANG . Lanthanide(Ⅲ) complexes derived from 4′-(2-pyridyl)-2, 2′∶6′, 2″-terpyridine: Crystal structures, fluorescent and magnetic properties. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1442-1451. doi: 10.11862/CJIC.20240114
18. [18]
  Yuyao Wang , Zhitao Cao , Zeyu Du , Xinxin Cao , Shuquan Liang . Research Progress of Iron-based Polyanionic Cathode Materials for Sodium-Ion Batteries. Acta Physico-Chimica Sinica, 2025, 41(4): 100035-. doi: 10.3866/PKU.WHXB202406014
19. [19]
  Yongzhi LI , Han ZHANG , Gangding WANG , Yanwei SUI , Lei HOU , Yaoyu WANG . A two-dimensional metal-organic framework for the determination of nitrofurantoin and nitrofurazone in aqueous solution. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 245-253. doi: 10.11862/CJIC.20240307
20. [20]
  Ji Qi , Jianan Zhu , Yanxu Zhang , Jiahao Yang , Chunting Zhang . Visible Color Change of Copper (II) Complexes in Reversible SCSC Transformation: The Effect of Structure on Color. University Chemistry, 2024, 39(3): 43-57. doi: 10.3866/PKU.DXHX202307050

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(383)
HTML views(75)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142