Citation: ZHAO Yue, HAN Xiao, ZHOU Xiao-Xia, LI Hai-Hua, YOU Zhong-Lu. Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(Ⅴ) Complexes with Hydrazones[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(4): 867-874. doi: 10.3969/j.issn.1001-4861.2013.00.140 shu

Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(Ⅴ) Complexes with Hydrazones

1.
1 Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China;

Received Date: 27 December 2012
Available Online: 17 January 2013
Fund Project: 国家自然科学基金(No.20901036) (No.20901036) 辽宁省高校优秀青年人才支持计划(No.LJQ2011114)资助项目。 (No.LJQ2011114)

In order to explore new and efficient urease inhibitors, two new oxovanadium(Ⅴ) complexes, [VOL¹(OCH₃)(CH₃OH)] (1) and [VOL₂(μ-OCH₃)]₂ (2) (H₂L¹=N′-(5-chloro-2-hydroxybenzylidene)-3-nitrobenzohydrazide; H₂L₂=N′-(5-chloro-2-hydroxybenzylidene)-4-chlorobenzohydrazide), have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. Compound 1 is a mononuclear complex, and compound 2 is a bis-methanolato bridged centrosymmetric dinuclear complex. The V atom in each complex adopts an octahedral coordination. Thermal stability and urease inhibitory activities of the complexes were studied. The percent inhibition at the concentration of 100 μmol·L^-1 on Helicobacter pylori urease is 71.4% for 1 and 73.3% for 2. The IC₅₀ values for 1 and 2 are 63.6 and 37.7 μmol·L^-1, respectively. CCDC: 858857, 1; and 858858, 2.
- hydrazone;oxovanadium(Ⅴ) complex;crystal structure;urease;inhibitor
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