基于多肽和温敏聚合物的光交联囊泡的制备及表征

引用本文: 袁康, 周雪, 杜建忠. 基于多肽和温敏聚合物的光交联囊泡的制备及表征[J]. 物理化学学报, 2017, 33(4): 656-660. doi: 10.3866/PKU.WHXB201701162 shu

Citation: YUAN Kang, ZHOU Xue, DU Jian-Zhong. Synthesis and Characterization of Thermo-Responsive Polypeptide-Based Vesicles with Photo-Cross-Linked Membranes[J]. Acta Physico-Chimica Sinica, 2017, 33(4): 656-660. doi: 10.3866/PKU.WHXB201701162 shu

基于多肽和温敏聚合物的光交联囊泡的制备及表征

1.
同济大学材料科学与工程学院, 高分子材料系, 上海 201804;
2.
同济大学附属上海市第十人民医院, 上海 200072
基金项目:
国家自然科学基金（21374080，21674081，21611130175），上海市科委国际合作项目（15230724500），上海千人计划，中央高校基本科研业务费（0500219211，1500219107）资助项目

摘要: 解决聚合物囊泡降解性和稳定性的矛盾是一个重要问题。本文通过可逆加成断裂链转移（RAFT）聚合和开环聚合（ROP）合成了一种聚[（N-异丙基丙烯酰胺-无规-7-（2-甲基丙烯酰氧基乙氧基）-4-甲基香豆素）-嵌段-（L-谷氨酸）] [P（NIPAM₄₅-stat-CMA₅）-b-PGA₄₂]的两亲嵌段共聚物。囊泡膜由温敏性的聚N-异丙基丙烯酰胺（PNIPAM）和可光交联聚7-（2-甲基丙烯酰氧基乙氧基）-4-甲基香豆素（PCMA）组成。由囊泡膜向内外舒展的聚谷氨酸（PGA）链使囊泡稳定分散在水中，并且可进一步官能化。透射电子显微镜（TEM）和动态光散射（DLS）表征证实了囊泡的形貌和尺寸分布。本研究为制备基于多肽共聚物的可降解温敏囊泡提供了一个范例，并有望在纳米生物医药领域得到应用。

关键词:

English

Synthesis and Characterization of Thermo-Responsive Polypeptide-Based Vesicles with Photo-Cross-Linked Membranes

1.
Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, P. R. China;
2.
Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China
Received Date: 12 December 2016
Revised Date: 16 January 2017
Available Online: 16 January 2017
Fund Project:
The project was supported by the National Natural Science Foundation of China (21374080, 21674081, 21611130175), Shanghai International Scientific Collaboration Fund, China (15230724500), Shanghai 1000 Talents Plan, and Fundamental Research Funds for the Central Universities, China (0500219211, 1500219107).

Abstract: It is an important challenge to balance the degradability and stability of polymer vesicles. We report a thermo-responsive vesicle based on poly[(N-isopropyl acrylamide-stat-7-(2-methacryloyloxyethoxy)-4-methylcoumarin)-b-(L-glutamic acid)] [P(NIPAM₄₅-stat-CMA₅)-b-PGA₄₂] diblock copolymer, which was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization and ring-opening polymerization (ROP). The membrane of the vesicle consists of thermo-responsive PNIPAM and photo-cross-linkable PCMA. The PGA chains in the vesicle coronas can colloidally stabilize the vesicles in water and can be postfunctionalized for further applications. Transmission electron microscopy and dynamic light scattering studies confirmed the formation of vesicles. Overall, we prepared a new functional thermo-responsive vesicle based on polypeptide copolymers that may be used as nanocarriers for the facile loading of a range of molecules in future.

Key words:

Vesicle
/ Peptide
/ Polymersome
/ Reversible addition fragmentation chain transfer
/ N-carboxyanhydride (NCA)

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

基于多肽和温敏聚合物的光交联囊泡的制备及表征

English

Synthesis and Characterization of Thermo-Responsive Polypeptide-Based Vesicles with Photo-Cross-Linked Membranes

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基于多肽和温敏聚合物的光交联囊泡的制备及表征

English

Synthesis and Characterization of Thermo-Responsive Polypeptide-Based Vesicles with Photo-Cross-Linked Membranes

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

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CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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