Citation: HE You-Zhou, LIU Yun, LIU Peng, FENG Wen, YUAN Li-Hua. Self-Assembly of Vesicles from Oli aramide Based on Multiple Hydrogen Bonds[J]. Acta Physico-Chimica Sinica, ;2014, 30(8): 1501-1508. doi: 10.3866/PKU.WHXB201406122 shu

Self-Assembly of Vesicles from Oli aramide Based on Multiple Hydrogen Bonds

1.
Key Laboratory for Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China

Received Date: 17 April 2014
Available Online: 12 June 2014
Fund Project:

Six-hydrogen-bonded oli aramide heteroduplexes demonstrate extremely high sequencespecificity and tunable stability during their self-assembly. The self-assembly behavior of molecular oli aramide 1 arrayed in a DADDAD-DADDAD sequence and that in the presence of oli aramide 2 with an ADAADAADAADA sequence were examined using multiple techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Results from these experiments indicate that 1 can self-assemble to vesicles with uniform shapes in both tetrahydrofuran/methanol (V/V, 85/15) and acetone, the size of which increased with an increase in solution concentration. Upon addition of the corresponding complementary 2, the vesicles turned into solid balls. Fluorescence microscopy experiments revealed that the vesicles were able to encapsulate the fluorescence molecules (Rhodamine B). With further modification of molecular structures, these vesicles may hold potential for applications as drug carrier as well as in controlled-release technology.
- Self-assembly,
- Vesicle,
- Oli aramide,
- Hydrogen bond,
- Molecular duplex
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