Home

Citation: ZHU Hui, WANG Mei, CHENG Ling-Li, ZHU Rong-Rong, SUN Xiao-Yu, YAO Si-De, WU Qing-Sheng, WANG Shi-Long. Photoionization and Photoexcitation Mechanisms of Salicylic Acid[J]. Acta Physico-Chimica Sinica, ;2010, 26(01): 87-93. doi: 10.3866/PKU.WHXB20091225 shu

Photoionization and Photoexcitation Mechanisms of Salicylic Acid

1.
School of Life Science and Technology, Tongji University, Shanghai 200092, P. R. China; Department of Chemisty, Tongji University, Shanghai 200092, P. R. China

Received Date: 26 May 2009
Available Online: 13 November 2009

Salicylic acid (SA), the active ingredient of aspirin, is effective in various medical treatments such as cosmetology and anticancer therapy. We investigated the photophysical and photochemical behavior of SA using 266 nm laser flash photolysis. Results demonstrate that SA can be photoionized and photoexcited by 266 nm photons to give SA+· and 3SA*. SA is highly photosensitive and can be photoionized via a monophotonic process with a quantum yield of 0.21. Under the aerobic conditions we find that in cells, hydrated electrons easily combine with oxygen to generate O-·20 , which can kill cancer cells. SA+·can be converted into neutral radicals by deprotonation and its pKa value is 2.95. SA also can be oxidized by SO-·4 and the rate constant is 2.28×109 L·mol-1·s-1, which further confirms the photoionization ability of SA. In addition, SA can be excited to 3SA*, which then generates 1O2*. This research provides introductory theory for the potential of SA to be used as an anticancer drug.
- Salicylic acid,
- Laser flash photolysis,
- Photoionization,
- Quantumyield,
- Anticancer mechainism
1. [1]
  Jianqiang Zheng , Yongbin Huang , Wencan Ming , Yingju Liu . Intelligent Reaction Optimization: Synthesis of Acetylsalicylic Acid Driven by Deep Learning and Optimization Algorithms. University Chemistry, 2025, 40(9): 87-98. doi: 10.12461/PKU.DXHX202411062
2. [2]
  Zian Lin , Yingxue Jin . Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) for Disease Marker Screening and Identification: A Comprehensive Experiment Teaching Reform in Instrumental Analysis. University Chemistry, 2024, 39(11): 327-334. doi: 10.12461/PKU.DXHX202403066
3. [3]
  Fengmiao Yu , Yang Sheng , Chanyue Li , Bao Li . The Three Lives of Aspirin. University Chemistry, 2024, 39(9): 115-121. doi: 10.12461/PKU.DXHX202402033
4. [4]
  Jingxuan Zhang , Weihao Jiang , Siyuan Zhang , Hongye Tian , Ziye Huang , Lin Huang , Qikun Wu , Jing Yang , Yibin Jiang , Cheng Wang . Automation and AI-Assisted Investigation of the Chemical Reactivity of Sulfosalicylic Acid. University Chemistry, 2026, 41(1): 332-345. doi: 10.12461/PKU.DXHX202505108
5. [5]
  Sihan Wang , Chenxi Yu , Shuzhang Ran , Jiawei Chen , Shoutong Rao , Xinyi Liang , Ruiqi Dong , Guixiang Zeng , Guoqiang Wang , Jing Ma . 铁配合物合成与性质探究的数智化改进——大学化学实验中“磺基水杨酸合铁配合物的组成与稳定常数的测定”的创新设计. University Chemistry, 2026, 41(5): 36-49. doi: 10.12461/PKU.DXHX202511137
6. [6]
  Xinting XIONG , Zhiqiang XIONG , Panlei XIAO , Xuliang NIE , Xiuying SONG , Xiuguang YI . Synthesis, crystal structures, Hirshfeld surface analysis, and antifungal activity of two complexes Na(Ⅰ)/Cd(Ⅱ) assembled by 5-bromo-2-hydroxybenzoic acid ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1661-1670. doi: 10.11862/CJIC.20240145
7. [7]
  Xudong Liu , Huili Fan , Junping Xiao , Min Yang , Yan Li . Teaching Approaches to the A_E + A_N Mechanism of Electrophilic Addition Reactions between Olefins and Inorganic Acids in Organic Chemistry. University Chemistry, 2025, 40(7): 367-372. doi: 10.12461/PKU.DXHX202409041
8. [8]
  Chunfang Zhang , Yuehua Liu , Lin Yang , Wenhui Xu , Mingtao Run , Cuimiao Zhang . 醋酸电离平衡常数测定实验的改进. University Chemistry, 2026, 41(5): 131-140. doi: 10.12461/PKU.DXHX202511002
9. [9]
  Zehui JIA , Bin WEN , Shuting ZHANG , Zhengliang ZHAO , Hongfei HAN , Chuntao WANG , Caimei FAN . Mechanism of carbon quantum dots-modified BiOCl/diatomite composites for ciprofloxacin degradation under visible light irradiation. Chinese Journal of Inorganic Chemistry, 2026, 42(2): 317-330. doi: 10.11862/CJIC.20250199
10. [10]
  Qi Liang , Xinxin Wang , Xinmiao Zhao , Mohan Yu , Yue Sun . 电子圆二色谱结合量子化学计算的氨基酸手性解析——介绍一个计算化学综合实验. University Chemistry, 2026, 41(5): 380-390. doi: 10.12461/PKU.DXHX202511096
11. [11]
  Weilai Yu , Chuanbiao Bie . Unveiling S-Scheme Charge Transfer Mechanism. Acta Physico-Chimica Sinica, 2024, 40(4): 2307022-0. doi: 10.3866/PKU.WHXB202307022
12. [12]
  Hongyu Cheng , Ruiyao Wang , Xingwen Sun . Mechanistic Study of the Classic Hofmann Elimination Reaction. University Chemistry, 2025, 40(12): 187-191. doi: 10.12461/PKU.DXHX202510104
13. [13]
  Xiuyun Wang , Faqiong Zhao , Yuwen Liu , Yijun Li , Yong Fan , Dongcheng Liu , Juanjuan Song , Yanping Ren , Wan Li , Yongxian Fan , Xiuqiong Zeng , Wenwei Zhang , Mei Shi , Min Hu , Xiaohang Qiu , Weihong Li , Jinarong Zhang , Shuyong Zhang . Spectrophotometry and Suggestions on Operating Specifications for Spectrophotometer. University Chemistry, 2026, 41(3): 200-207. doi: 10.12461/PKU.DXHX202507116
14. [14]
  Weizhe Liu , Minghui Shi , Ruiqi Zhu , Bin Pan , Guofu Huang . 抗癌药物艾乐替尼的生物电子等排体的合成. University Chemistry, 2026, 41(5): 210-221. doi: 10.12461/PKU.DXHX202510066
15. [15]
  Huasen Lu , Shixu Song , Qisen Jia , Guangbo Liu , Luhua Jiang . Advances in Cu₂O-based Photocathodes for Photoelectrochemical Water Splitting. Acta Physico-Chimica Sinica, 2024, 40(2): 2304035-0. doi: 10.3866/PKU.WHXB202304035
16. [16]
  Jingjing QING , Fan HE , Zhihui LIU , Shuaipeng HOU , Ya LIU , Yifan JIANG , Mengting TAN , Lifang HE , Fuxing ZHANG , Xiaoming ZHU . Synthesis, structure, and anticancer activity of two complexes of dimethylglyoxime organotin. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1301-1308. doi: 10.11862/CJIC.20240003
17. [17]
  Tangsheng Guan , Ruizhi Yang , Pingyue Geng , Yuhong Lin , Shui Hu , Xiaojuan Chen , Houjin Li , Yong Shen . Innovative Digital Experiments for Glutathione-Targeted Anticancer Drugs in Redox Systems. University Chemistry, 2026, 41(1): 144-158. doi: 10.12461/PKU.DXHX202505028
18. [18]
  Chi Zhang , Yi Xu , Xiaopeng Guo , Zian Jie , Ling Li . 五彩斑斓的秘密——物质显色机理. University Chemistry, 2025, 40(6): 266-275. doi: 10.12461/PKU.DXHX202407061
19. [19]
  Chun-Lin Sun , Yaole Jiang , Yu Chen , Rongjing Guo , Yongwen Shen , Xinping Hui , Baoxin Zhang , Xiaobo Pan . Construction, Performance Testing, and Practical Applications of a Home-Made Open Fluorescence Spectrometer. University Chemistry, 2024, 39(5): 287-295. doi: 10.3866/PKU.DXHX202311096
20. [20]
  Xingchao Zhao , Xiaoming Li , Ming Liu , Zijin Zhao , Kaixuan Yang , Pengtian Liu , Haolan Zhang , Jintai Li , Xiaoling Ma , Qi Yao , Yanming Sun , Fujun Zhang . Photomultiplication-Type All-Polymer Photodetectors and Their Applications in Photoplethysmography Sensor. Acta Physico-Chimica Sinica, 2025, 41(1): 100007-0. doi: 10.3866/PKU.WHXB202311021

Get Citation

PDF

XML

Metrics

PDF Downloads(1439)
Abstract views(3531)
HTML views(62)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return