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Citation: Chen Hong-Ming, Zhou Jia-Ju, Xie Gui-Rong, Pang Su-Hua. The Studies on Pharmacophore Model of K⁺ Channel Opener[J]. Acta Physico-Chimica Sinica, ;1997, 13(02): 101-105. doi: 10.3866/PKU.WHXB19970202 shu

The Studies on Pharmacophore Model of K⁺ Channel Opener

1.
Laboratory of Computer Chemostry,Institute of Chemical Metallurgy,Chinese Academy of Science,Beijing 100080

Received Date: 28 October 1996
Available Online: 15 February 1997

In this paper, a set of ATP sensitive K+ channel openers (KCO), whose structure are different, were investigated with the aim to develope our previously defined KCO's pharmacophore model. To validate the effectiveness of the pharmacophore model, A comparative molecule field analysis (CoMFA) was proceeded, aligning the molecules according to the requirernent of the model, and od results were obtained. This pharmacophore model may be a start point to design new KCO compounds.
- K⁺ channel opener,
- CoMFA,
- Pharmacophore model
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The Studies on Pharmacophore Model of K⁺ Channel Opener