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Citation: Wu Pei-Qiang, Ma Xing-Qi, Wu Qi. Laser Light Scattering Investigation of the Aggregation Process of Trichosanthin in Aqueous Solution[J]. Acta Physico-Chimica Sinica, ;1995, 11(04): 331-336. doi: 10.3866/PKU.WHXB19950409 shu

Laser Light Scattering Investigation of the Aggregation Process of Trichosanthin in Aqueous Solution

1.
Department of Chemistry,Peking University,Beijing 100871

Received Date: 1 June 1994
Available Online: 15 April 1995

Trichosanthin (TCS) is a single-chain protein containing 247 amino acid residues, it belongs to the plant ribosome-inactivating protein (RIP). The isoelectric point is about 9.4 and the mole mass is about 2.7×104 g•mol-1. It is an effective plant protein of a popular chinese herb medicine and a kind of cytotoxin. Recently, it has been reported that it can be used to inhibit trophoblastic tumors and may also be useful in the treatment of AIDS disease, and therefore has attracted moe attention to the RIP and its applications. However, the problem encoutered is its low stability in blood and tissue fluids. It has become essential to understand the behaviour of TCS in solution.
- Laser light scattering,
- Trichosanthin,
- Aggregation process
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