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Citation: Fan Xiaoling, Zhu Minhui*, Fu Heng. THE CONFORMATIONAL ANALYSIS OF 4′-R-3,3-DIALKYLPHENYL-TRIAZENES ON ANTITUMOR POTENCY[J]. Acta Physico-Chimica Sinica, ;1989, 5(04): 392-394. doi: 10.3866/PKU.WHXB19890403 shu

THE CONFORMATIONAL ANALYSIS OF 4′-R-3,3-DIALKYLPHENYL-TRIAZENES ON ANTITUMOR POTENCY

1.
The Institute of Electronics; Academia Sinica; The Institute of Chemistry; Academia Sinica

Received Date: 11 January 1989
Available Online: 15 August 1989

Using the MMPI program and 3-D high resolution molecular modeling system, a preliminary structure-activity relationship (SAR) based upon molecular shape analysis has been developed for a set of 20 4-R-3, 3-dialkylphenyl-triazenes for which antitumor potency against L1712 Leukemia in mice is reported. The SAR suggests that for antitumor potency, here is a significant difference between the shapes of the active and inactive molecules.
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