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Citation: Yuena Yu, Fang Fang. Microwave-Assisted Synthesis of Safinamide Methanesulfonate[J]. University Chemistry, ;2024, 39(11): 210-216. doi: 10.3866/PKU.DXHX202401076 shu

Microwave-Assisted Synthesis of Safinamide Methanesulfonate

Yuena Yu ,
Fang Fang

Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, Guangdong Province, China

Received Date: 26 January 2024
Revised Date: 6 March 2024

This study focuses on the design of a teaching experiment of synthesizing safinamide methanesulfonate, a drug for treating Alzheimer’s disease. Starting from 4-(3-fluorobenzyloxy)benzaldehyde, the microwave synthesis technique was employed in a reductive amination strategy to rapidly and efficiently obtain the target product through three consecutive reactions. The product’s structure and purity were confirmed through NMR, melting point, and specific rotation analysis. This experiment not only enhances students’ organic synthesis skills but also emphasizes the integration of knowledge across disciplines.
- Safinamide methanesulfonate,
- Microwave-assisted synthesis,
- Reductive amination
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