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Citation: Feng Li, Ranran Meng, Hanzhi Zhang, Yingjuan Qu, Jingwu Kang. Determination of Stereoisomeric Impurities of Glycopyrrolate Bromide by Capillary Electrophoresis: Recommendation of a Pharmaceutical Analysis Experiment[J]. University Chemistry, ;2023, 38(12): 67-74. doi: 10.3866/PKU.DXHX202307023 shu

Determination of Stereoisomeric Impurities of Glycopyrrolate Bromide by Capillary Electrophoresis: Recommendation of a Pharmaceutical Analysis Experiment

Feng Li ^1,, ,
Ranran Meng ² ,
Hanzhi Zhang ³ ,
Yingjuan Qu ¹ ,
Jingwu Kang ^2,,

1.
Xi'an Key Laboratory of Food Safety Testing and Risk Assessment, School of Chemical Engineering, Xi'an University, Xi'an 710065, China;
2.
State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;
3.
Abiochem Biotechnology Co., Ltd., Shanghai 200241, China

Corresponding author: Feng Li, Jingwu Kang,
Received Date: 10 July 2023

This article recommends a pharmaceutical analysis experiment “chiral capillary electrophoresis analysis of the stereoisomers of the drug Glycopyrrolate bromide”. The experiment includes the selection of cyclodextrin chiral selector, optimization of capillary electrophoresis separation conditions, and construction of a standard curve. From the perspective of pharmaceutical analysis, this experiment focuses on introducing the principle of capillary electrophoresis analysis, the principle of chiral separation, and the importance of analyzing stereoisomeric impurities in drugs. It is suggested to be offered in majors such as applied chemistry, pharmacy, and pharmaceutical engineering.
- Capillary electrophoresis,
- Chiral analysis,
- Glycopyrrolate bromide,
- Cyclodextrin,
- Pharmaceutical analysis experiment
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