Citation: Kexing Ma, Xiao Zhang, Xin-Ping Hui, Quan-Xiang Wu. Advancements in Oral Antihypertensive Medication Research[J]. University Chemistry, ;2023, 38(12): 106-113. doi: 10.3866/PKU.DXHX202306030 shu

Advancements in Oral Antihypertensive Medication Research

1.
College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China;
2.
School of Public Health, Lanzhou University, Lanzhou 730000, China

Corresponding author: Xin-Ping Hui, Quan-Xiang Wu,
Received Date: 13 June 2023

This article reviews research on antihypertensive medications including vasodilators, β-blockers, and angiotensin II receptor antagonists that have been approved by the FDA (Food and Drug Administration) since 2011. It covers the discovery of lead compounds, mechanisms of action, structural modifications, structure-activity relationships, and synthesis methods, aiming to serve as a reference for the development of antihypertensive drugs.
- Antihypertensive drugs,
- Lead compounds,
- Structural modification,
- Structure-activity relationship
1. [1]
2. [2]
3. [3]
4. [4]
  Gao, Q.; Xu, L.; Cai, J. BBA-Mol. Basis Dis. 2021, 1867, 166037.
5. [5]
  Asaki, T.; Kuwano, K.; Morrison, K.; Gatfield, J.; Hamamoto, T.; Clozel, M. J. Med. Chem. 2015, 58, 7128.
6. [6]
  Moncada, S.; Gryglewski, R.; Bunting, S.; Vane, J. R. Nature 1976, 263, 663.
7. [7]
  Sitbon, O.; Channick, R.; Chin, K. M.; Frey, A.; Gaine, S.; Galiè, N.; Ghofrani, H.-A.; Hoeper, M. M.; Lang, I. M.; Preiss, R.; et al. N. Engl. J. Med. 2015, 373, 2522.
8. [8]
  Skuballa, W.; Schillinger, E.; Stuerzebecher, C. S.; Vorbrueggen, H. J. Med. Chem. 1986, 29, 313.
9. [9]
  Meanwell, N. A.; Rosenfeld, M. J.; Wright, J. J. K.; Brassard, C. L.; Buchanan, J. O.; Federici, M. E.; Fleming, J. S.; Seiler, S. M. J. Med. Chem. 1992, 35, 389.
10. [10]
  Meanwell, N. A.; Rosenfeld, M. J.; Trehan, A. K.; Romine, J. L.; Wright, J. J. K.; Brassard, C. L.; Buchanan, J. O.; Federici, M. E.; Fleming, J. S.; Gamberdella, M.; et al. J. Med. Chem. 1992, 35, 3498.
11. [11]
  Asaki, T.; Kuwano, K.; Morrison, K.; Gatfield, J.; Hamamoto, T.; Clozel, M. J. Med. Chem. 2015, 58, 7128.
12. [12]
  Kuwano, K.; Hashino, A.; Asaki, T.; Hamamoto, T.; Yamada, T.; Okubo, K.; Kuwabara, K. J. Pharmacol. Exp. Ther. 2007, 322, 1181.
13. [13]
14. [14]
  Asaki, T.; Hamamoto, T.; Kuwano, K. Heterocyclic compound derivatives and medicines. USA 07205302B2, 2007-04-17.
15. [15]
16. [16]
  Black, J. W.; Stephenson, J. S. Lancet 1962, ii, 311.
17. [17]
18. [18]
  Barrett, A. M.; Cullum, V. A. Brit. J. Pharmacol. 1968, 34, 43.
19. [19]
  Wikstrand, J.; Warnold, I.; Olsson, G.; Tuomilehto, J.; Elmfeldt, D.; Berglund, G.; Barber, H. J.; Eliasson, K.; Jastrup, B.; Karatzas, N. B.; et al. J. Am. Med. Assoc. 1988, 259, 1976.
20. [20]
  Tuomilehto, J.; Wikstrand, J.; OIsson, G.; Elmfeldt, D.; Warnold, I.; Barber, H.; Eliasson, K.; Jastrup. B.; Karatzas, N.; Leer, J. Hypertension 1989, 13, 773.
21. [21]
  Sandberg, A.; Ragnarsson, G.; Jonsson, U. E.; Sjögren, J. Eur. J. Clin. Pharmacol. 1988, 33, S3.
22. [22]
  Gurjar, M. K.; Joshi, S. V.; Sastry, B. S.; Rao, A. V. R. Synth. Commun. 1990, 20, 3489.
23. [23]
24. [24]
25. [25]
26. [26]
  Ji, H.; Leung, M.; Zhang, Y.; Catt, K. J.; Sandberg, K. J. Biol. Chem. 1994, 269, 16533.
27. [27]
28. [28]
  Scheen, A. J. Diabetes Metab. 2004, 30, 487.
29. [29]
30. [30]
1. [1]
  Lei Feng , Ze-Min Zhu , Ying Yang , Zongbin He , Jiafeng Zou , Man-Bo Li , Yan Zhao , Zhikun Wu . Long-Pursued Structure of Au₂₃(S-Adm)₁₆ and the Unexpected Doping Effects. Acta Physico-Chimica Sinica, 2024, 40(5): 2305029-0. doi: 10.3866/PKU.WHXB202305029
2. [2]
  Ruizhi Duan , Xiaomei Wang , Panwang Zhou , Yang Liu , Can Li . The role of hydroxyl species in the alkaline hydrogen evolution reaction over transition metal surfaces. Acta Physico-Chimica Sinica, 2025, 41(9): 100111-0. doi: 10.1016/j.actphy.2025.100111
3. [3]
  Xuejie Wang , Guoqing Cui , Congkai Wang , Yang Yang , Guiyuan Jiang , Chunming Xu . Research Progress on Carbon-based Catalysts for Catalytic Dehydrogenation of Liquid Organic Hydrogen Carriers. Acta Physico-Chimica Sinica, 2025, 41(5): 100044-0. doi: 10.1016/j.actphy.2024.100044
4. [4]
  Haiying Jiang , Liuhong Song , Yangyang Cheng , Kefen Yue , Mingli Peng , Huilin Guo . Ph―C≡C―Cu_2.5的力致变色现象探究——推荐一个物理化学实验. University Chemistry, 2025, 40(8): 249-254. doi: 10.12461/PKU.DXHX202410003
5. [5]
  Xue-Peng Zhang , Yuchi Long , Yushu Pan , Jiding Wang , Baoyu Bai , Rui Ding . 定量构效关系方法学习探索：以钴卟啉活化氧气为例. University Chemistry, 2025, 40(8): 345-359. doi: 10.12461/PKU.DXHX202410107
6. [6]
  Qiaowen CHANG , Ke ZHANG , Guangying HUANG , Nuonan LI , Weiping LIU , Fuquan BAI , Caixian YAN , Yangyang FENG , Chuan ZUO . Syntheses, structures, and photo-physical properties of iridium phosphorescent complexes with phenylpyridine derivatives bearing different substituting groups. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 235-244. doi: 10.11862/CJIC.20240311
7. [7]
  Hao Wu , Zhen Liu , Dachang Bai . ¹H NMR Spectrum of Amide Compounds. University Chemistry, 2024, 39(3): 231-238. doi: 10.3866/PKU.DXHX202309020
8. [8]
  Qianlang Wang , Jijun Sun , Qian Chen , Quanqin Zhao , Baojuan Xi . The Appeal of Organophosphorus Compounds: Clearing Their Name. University Chemistry, 2025, 40(4): 299-306. doi: 10.12461/PKU.DXHX202405205
9. [9]
  Chi Li , Jichao Wan , Qiyu Long , Hui Lv , Ying Xiong . N-Heterocyclic Carbene (NHC)-Catalyzed Amidation of Aldehydes with Nitroso Compounds. University Chemistry, 2024, 39(5): 388-395. doi: 10.3866/PKU.DXHX202312016
10. [10]
  Ying Xiong , Guangao Yu , Lin Wu , Qingwen Liu , Houjin Li , Shuanglian Cai , Zhanxiang Liu , Xingwen Sun , Yuan Zheng , Jie Han , Xin Du , Chengshan Yuan , Qihan Zhang , Jianrong Zhang , Shuyong Zhang . Basic Operations and Specification Suggestions for Determination of Physical Constants of Organic Compounds. University Chemistry, 2025, 40(5): 106-121. doi: 10.12461/PKU.DXHX202503079
11. [11]
  Yongjian Zhang , Fangling Gao , Hong Yan , Keyin Ye . Electrochemical Transformation of Organosulfur Compounds. University Chemistry, 2025, 40(5): 311-317. doi: 10.12461/PKU.DXHX202407035
12. [12]
  Nan Xiao , Fang Sun . 二芳基硫醚化合物的构建及应用. University Chemistry, 2025, 40(6): 360-363. doi: 10.12461/PKU.DXHX202407099
13. [13]
  Tianqi Bai , Kun Huang , Fachen Liu , Ruochen Shi , Wencai Ren , Songfeng Pei , Peng Gao , Zhongfan Liu . Nanoscale Mechanism of Microstructure-Dependent Thermal Diffusivity in Thick Graphene Sheets. Acta Physico-Chimica Sinica, 2025, 41(3): 2404024-0. doi: 10.3866/PKU.WHXB202404024
14. [14]
  Geyang Song , Dong Xue , Gang Li . Recent Advances in Transition Metal-Catalyzed Synthesis of Anilines from Aryl Halides. University Chemistry, 2024, 39(2): 321-329. doi: 10.3866/PKU.DXHX202308030
15. [15]
  Jiaming Xu , Yu Xiang , Weisheng Lin , Zhiwei Miao . Research Progress in the Synthesis of Cyclic Organic Compounds Using Bimetallic Relay Catalytic Strategies. University Chemistry, 2024, 39(3): 239-257. doi: 10.3866/PKU.DXHX202309093
16. [16]
  Aidang Lu , Yunting Liu , Yanjun Jiang . Comprehensive Organic Chemistry Experiment: Synthesis and Characterization of Triazolopyrimidine Compounds. University Chemistry, 2024, 39(8): 241-246. doi: 10.3866/PKU.DXHX202401029
17. [17]
  Xilin Zhao , Xingyu Tu , Zongxuan Li , Rui Dong , Bo Jiang , Zhiwei Miao . Research Progress in Enantioselective Synthesis of Axial Chiral Compounds. University Chemistry, 2024, 39(11): 158-173. doi: 10.12461/PKU.DXHX202403106
18. [18]
  Hanxue LIU , Shijie LI , Meng REN , Xuling XUE , Hongke LIU . Design and antitumor properties of dehydroabietic acid functionalized cyclometalated iridium(Ⅲ) complex. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1483-1494. doi: 10.11862/CJIC.20250031
19. [19]
  Xiaofeng Zhu , Bingbing Xiao , Jiaxin Su , Shuai Wang , Qingran Zhang , Jun Wang . Transition Metal Oxides/Chalcogenides for Electrochemical Oxygen Reduction into Hydrogen Peroxides. Acta Physico-Chimica Sinica, 2024, 40(12): 2407005-0. doi: 10.3866/PKU.WHXB202407005
20. [20]
  Jinfeng Chu , Lan Jin , Yu-Fei Song . Exploration and Practice of Flipped Classroom in Inorganic Chemistry Experiment: a Case Study on the Preparation of Inorganic Crystalline Compounds. University Chemistry, 2024, 39(2): 248-254. doi: 10.3866/PKU.DXHX202308016

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(947)
HTML views(138)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142