Citation: Manle Jiang, Dang Zhang, Jian Zhang, Ping Xu, Lei Wang. Micro/nanorobots: An “Ingenious Shocking Military” towards Cancer Treatment[J]. University Chemistry, ;2023, 38(11): 142-147. doi: 10.3866/PKU.DXHX202304034 shu

Micro/nanorobots: An “Ingenious Shocking Military” towards Cancer Treatment

Manle Jiang ¹ ,
Dang Zhang ¹ ,
Jian Zhang ² ,
Ping Xu ¹ ,
Lei Wang ^1,,

1.
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China;
2.
School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China

Corresponding author: Lei Wang, leiwang_chem@hit.edu.cn
Received Date: 10 April 2023

In recent decades, an escalating incidence of tumors has been observed, necessitating more precise and less side-effect-prone therapies. Micro/nanorobots have been successfully engineered to address this challenge. These minute intelligent machines are capable of navigating to, and even infiltrating, tumor cells or tissues under external control. This enables targeted drug delivery and precise tumor therapy. To elucidate this sophisticated technology to a general audience, this paper adopts a personification style. Utilizing an engaging "battle narrative between micro/nanorobots and tumor cells", we briefly outline the design, fabrication, propulsion mechanisms, and therapeutic principles for a wider readership.
- Micro/nanomotors,
- Tumor treatment,
- Micro/nanorobots,
- Targeted treatment,
- Immunotherapy
1. [1]
2. [2]
3. [3]
  Wang, J.; Dong, R.; Wu, H.; Cai, Y.; Ren, B. Micro Nano Lett. 2020, 12, 11.
4. [4]
  Lin, Z.; Gao, C.; Wang, D.; He, Q. Angew. Chem. Int. Edit. 2021, 60 (16), 8750.
5. [5]
  Garcia-Gradilla, V.; Sattayasamitsathit, S.; Soto, F.; Kuralay, F.; Yardimci, C.; Wiitala, D.; Galarnyk, M.; Wang, J. Small 2014, 10 (20), 4154.
6. [6]
  Ke, L.; Wei, F.; Liao, X.; Rees, T.; Kuang, S.; Liu, Z.; Chen, Y.; Ji, L.; Chao, H. Nanoscale 2021, 13 (16), 7590.
7. [7]
  Song, X.; Chen, Z.; Zhang, X.; Xiong, J.; Jiang, T.; Wang, Z.; Geng, X.; Cheang, U. K. Sci. Rep. 2021, 11, 7907.
8. [8]
  Song, X.; Fu, W.; Cheang, U. K. Iscience 2022, 25 (7), 104507.
9. [9]
  Llopic-Lorente, A.; Garcia, A.; Murillo, N.; Hortelao, A. C.; Patino, T.; Villalonga, R.; Sancenon, F.; Martinez, R.; Sanchez, S. ACS Nano 2019, 13 (10), 12171.
10. [10]
  Gong, D.; Geli, N.; Zhang, D.; Cai, J. ACS Appl. Mater. Inter. 2022, 14 (5), 6320.
11. [11]
  Ceylan, H.; Yasa, I. C.; Yasa, O.; Tabak, A. F.; Giltinan, J.; Sitti, M. ACS Nano 2019, 13 (3), 3353.
12. [12]
13. [13]
  Kagan, D.; Laocharoensuk, R.; Zimmerman, M.; Clawson, C.; Balasubramanian, S.; Kong, D.; Bishop, D.; Sattayasamitsathit, S.; Zhang, L. F.; Wang, J. Small 2010, 6 (23), 2741.
14. [14]
  Wang, D.; Gao, C.; Wang, W.; Sun, M.; Guo, B.; Xie, H.; He, Q. ACS Nano 2018, 12 (10), 10212.
15. [15]
  Yang, H.; Wang, L.; Huang, X. Coordin. Chem. Rev. 2023, 495, 215372.
1. [1]
  Gaofeng Zeng , Shuyu Liu , Manle Jiang , Yu Wang , Ping Xu , Lei Wang . Micro/Nanorobots for Pollution Detection and Toxic Removal. University Chemistry, 2024, 39(9): 229-234. doi: 10.12461/PKU.DXHX202311055
2. [2]
  Shuyu Liu , Xiaomin Sun , Bohan Song , Gaofeng Zeng , Bingbing Du , Chongshen Guo , Cong Wang , Lei Wang . Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications. University Chemistry, 2024, 39(11): 182-188. doi: 10.12461/PKU.DXHX202404113
3. [3]
  Xin Lv , Hongxing Zhang , Kaibo Duan , Wenhui Dai , Zhihui Wen , Wei Guo , Junsheng Hao . Lighting the Way Against Cancer: Photodynamic Therapy. University Chemistry, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090
4. [4]
  Tingting XU , Wenjing ZHANG , Yongbo SONG . Research advances of atomic precision coinage metal nanoclusters in tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2275-2285. doi: 10.11862/CJIC.20240229
5. [5]
  Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
6. [6]
  Jiahui CHEN , Tingting ZHENG , Xiuyun ZHANG , Wei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106
7. [7]
  Zhuoya WANG , Le HE , Zhiquan LIN , Yingxi WANG , Ling LI . Multifunctional nanozyme Prussian blue modified copper peroxide: Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2445-2454. doi: 10.11862/CJIC.20240194
8. [8]
  Shiyang He , Dandan Chu , Zhixin Pang , Yuhang Du , Jiayi Wang , Yuhong Chen , Yumeng Su , Jianhua Qin , Xiangrong Pan , Zhan Zhou , Jingguo Li , Lufang Ma , Chaoliang Tan . Pt Single-Atom-Functionalized 2D Al-TCPP MOF Nanosheets for Enhanced Photodynamic Antimicrobial Therapy. Acta Physico-Chimica Sinica, 2025, 41(5): 100046-0. doi: 10.1016/j.actphy.2025.100046
9. [9]
  Peng GENG , Guangcan XIANG , Wen ZHANG , Haichuang LAN , Shuzhang XIAO . Hollow copper sulfide loaded protoporphyrin for photothermal-sonodynamic therapy of cancer cells. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1903-1910. doi: 10.11862/CJIC.20240155
10. [10]
  Wenjing ZHANG , Xiaoqing WANG , Zhipeng LIU . Recent developments of inorganic metal complex-based photothermal materials and their applications in photothermal therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2356-2372. doi: 10.11862/CJIC.20240254
11. [11]
  Fa Wang , Yu Chen , Hui Chao . Ruthenium(II) Complexes as Photoactivated Chemo-Prodrugs for Hypoxic Tumor Therapy. University Chemistry, 2025, 40(7): 200-212. doi: 10.12461/PKU.DXHX202410024
12. [12]
  Xue Wu , Yupeng Liu , Bingzhe Wang , Lingyun Li , Zhenjian Li , Qingcheng Wang , Quansheng Cheng , Guichuan Xing , Songnan Qu . Rationally assembling different surface functionalized carbon dots for enhanced near-infrared tumor photothermal therapy. Acta Physico-Chimica Sinica, 2025, 41(9): 100109-0. doi: 10.1016/j.actphy.2025.100109
13. [13]
  Bin SUN , Heyan JIANG . Glucose-modified bis-Schiff bases: Synthesis and bio-activities in Alzheimer′s disease therapy. Chinese Journal of Inorganic Chemistry, 2025, 41(7): 1338-1350. doi: 10.11862/CJIC.20240428
14. [14]
  Zijian Jiang , Yuang Liu , Yijian Zong , Yong Fan , Wanchun Zhu , Yupeng Guo . Preparation of Nano Zinc Oxide by Microemulsion Method and Study on Its Photocatalytic Activity. University Chemistry, 2024, 39(5): 266-273. doi: 10.3866/PKU.DXHX202311101
15. [15]
  Jian Li , Yu Zhang , Rongrong Yan , Kaiyuan Sun , Xiaoqing Liu , Zishang Liang , Yinan Jiao , Hui Bu , Xin Chen , Jinjin Zhao , Jianlin Shi . Highly Efficient, Targeted, and Traceable Perovskite Nanocrystals for Photoelectrocatalytic Oncotherapy. Acta Physico-Chimica Sinica, 2025, 41(5): 100042-0. doi: 10.1016/j.actphy.2024.100042
16. [16]
  Qi Li , Pingan Li , Zetong Liu , Jiahui Zhang , Hao Zhang , Weilai Yu , Xianluo Hu . Fabricating Micro/Nanostructured Separators and Electrode Materials by Coaxial Electrospinning for Lithium-Ion Batteries: From Fundamentals to Applications. Acta Physico-Chimica Sinica, 2024, 40(10): 2311030-0. doi: 10.3866/PKU.WHXB202311030
17. [17]
  Yu Wang , Shoulei Zhang , Tianming Lv , Yan Su , Xianyu Liu , Fuping Tian , Changgong Meng . Introduce a Comprehensive Inorganic Synthesis Experiment: Synthesis of Nano Zinc Oxide via Microemulsion Using Waste Soybean Oil. University Chemistry, 2024, 39(7): 316-321. doi: 10.3866/PKU.DXHX202311035
18. [18]
  Min Gu , Huiwen Xiong , Liling Liu , Jilie Kong , Xueen Fang . Rapid Quantitative Detection of Procalcitonin by Microfluidics: An Instrumental Analytical Chemistry Experiment. University Chemistry, 2024, 39(4): 87-93. doi: 10.3866/PKU.DXHX202310120
19. [19]
  Xiaojun Liu , Lang Qin , Yanlei Yu . Dynamic Manipulation of Photonic Bandgaps in Cholesteric Liquid Crystal Microdroplets for Applications. Acta Physico-Chimica Sinica, 2024, 40(5): 2305018-0. doi: 10.3866/PKU.WHXB202305018
20. [20]
  Sumiya Akter Dristy , Md Ahasan Habib , Shusen Lin , Mehedi Hasan Joni , Rutuja Mandavkar , Young-Uk Chung , Md Najibullah , Jihoon Lee . Exploring Zn doped NiBP microspheres as efficient and stable electrocatalyst for industrial-scale water splitting. Acta Physico-Chimica Sinica, 2025, 41(7): 100079-0. doi: 10.1016/j.actphy.2025.100079

Get Citation

PDF

XML

Metrics

PDF Downloads(5)
Abstract views(813)
HTML views(147)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142