Citation: Hengyu Li, Chengyang Lai, Amelia Siqi Huang, Xing Chen. Basics and Frontiers of Click Chemistry and Bioorthogonal Chemistry: A Brief Introduction to 2022 Nobel Prize in Chemistry[J]. University Chemistry, ;2023, 38(1): 1-7. doi: 10.3866/PKU.DXHX202212058 shu

Basics and Frontiers of Click Chemistry and Bioorthogonal Chemistry: A Brief Introduction to 2022 Nobel Prize in Chemistry

1.
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
2.
Dalton Academy, The Affiliated High School of Peking University, Beijing 100190, China

Corresponding author: Xing Chen, xingchen@pku.edu.cn
Received Date: 20 December 2022

The 2022 Nobel Prize in Chemistry was awarded to Carolyn R. Bertozzi, Morten Meldal, and K. Barry Sharpless, for the development of click chemistry and bioorthogonal chemistry. Stemming from the advances on the methodology of organic synthesis, click chemistry provides a versatile tool for coupling molecules with high efficiency under mild conditions. Orignially developed for specific labeling and visualization of glycans–an important biomacromolecule in living systems–bioorthogonal chemistry is a class of ligation reactions which neither interfere with nor being interfered by the surrounding biological milieu. Click chemistry and bioorthogonal chemistry are interconnected through similar philosophy and have emerged as the most useful chemical reactions in chemistry, biomedicine, and material science. Here, we briefly introduce the fundamental concepts and frontiers related to click chemistry and bioorthogonal chemistry.
- Nobel Prize in Chemistry,
- Click chemistry,
- Bioorthogonal chemistry
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