Citation: Fengyun Li,  Lei Zhou,  Lin Zhang,  Qiaosheng Pu. Being Precise on Microscale: Exploration on Introducing Microfluidics into Teaching of Analytical Chemistry[J]. University Chemistry, ;2023, 38(9): 89-97. doi: 10.3866/PKU.DXHX202210081 shu

Being Precise on Microscale: Exploration on Introducing Microfluidics into Teaching of Analytical Chemistry

  • Corresponding author: Qiaosheng Pu, puqs@lzu.edu.cn
  • Received Date: 26 October 2022

  • The microfluidics has been widely applied in analytical chemistry and many other fields ascribed to its excellent ability to manipulate fluids on the microscale. The introduction of microfluidics to the undergraduate courses of analytical chemistry will expand the cutting-edge contents, help the teaching process and improve students' learning interest. Herein, we review the history of microfluidics, summarize the ideological and political elements in these contents, briefly introduce the important theories in the area of microfluidics and fabrication processes of microfluidic chips, and discuss their relationship with analytical chemistry. Recent research progresses of the microfluidics in the fields of analytical chemistry research are presented with a focus on bioanalysis. We hope this can be a reference for the introduction of microfluidics into the teaching of analytical chemistry.
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    1. [1]

    2. [2]

    3. [3]

      Nguyen, N. T.; Wereley, S. T. Fundamental and Applications of Microfluidics, 2nd ed.; ArtechHouse:Boston, USA, 2006.

    4. [4]

    5. [5]

      Micheli, A. J.; Thomas, V.; Grillo, F.; Kapur, M.; Schuerle, S. J. Chem. Educ. 2022, 99 (3), 1272.

    6. [6]

    7. [7]

    8. [8]

    9. [9]

    10. [10]

    11. [11]

      Terry, S. C.; Herman, J. H.; Angell, J. B. IEEE Trans. Electron. Dev. 1979, 26 (12), 1880.

    12. [12]

      Manz, A.; Graber, N.; Widmer, H. M. Sensor. Actuat. B-Chem. 1990, 1, 244.

    13. [13]

      Duffy, D. C.; McDonald, J. C.; Schueller, O. J.; Whitesides, G. M. Anal. Chem. 1998, 70, 4974.

    14. [14]

      Thorsen, T.; Maerkl, S. J.; Quake, S. R. Science 2002, 298 (5593), 580.

    15. [15]

      Martinez, A. W.; Phillips, S. T.; Butte, M. J.; Whitesides, G. M. Angew. Chem. Int. Ed. 2007, 46 (8), 1318.

    16. [16]

    17. [17]

      Deshmukh, S. S.; Goswami, A. Mater. Manuf. Process. 2021, 36 (5), 501.

    18. [18]

      Hansen, T. S.; Selmeczi, D.; Larsen, N. B. J. Micromech. Microeng. 2010, 20 (1), 015020.

    19. [19]

    20. [20]

      Reynolds, O. Philos. Trans. R. Soc. London 1883, 174, 935.

    21. [21]

      Shang, L.; Cheng, Y.; Zhao, Y. Chem. Rev. 2017, 117 (12), 7964.

    22. [22]

      Tabelling, P. Introduction to Microfluidics; Oxford Press:Oxford, USA, 2005.

    23. [23]

    24. [24]

      Lin, C. H.; Hsiao, Y. H.; Chang, H. C.; Yeh, C. F.; He, C. K.; Salm, E. M.; Chen, C.; Chiu, I. M.; Hsu, C. H. Lab Chip 2015, 15 (14), 2928.

    25. [25]

      Kim, H. S.; Devarenneb, T. P.; Han, A. Lab Chip 2015, 15 (11), 2467.

    26. [26]

      Huebner, A.; Olguin, L. F.; Bratton, D.; Whyte, G.; Huck, W. T. S.; de Mello, A. J.; Edel, J. B.; Abell, C.; Hollfelder, F. Anal. Chem. 2008, 80, 3890.

    27. [27]

      Baret, J. C.; Miller, O. J.; Taly, V.; Ryckelynck, M.; Harrak, A. E.; Frenz, L.; Rick, C.; Samuels, M. L.; Hutchison, J. B.; Agresti, J. J.; et al. Lab Chip 2009, 9 (13), 1850.

    28. [28]

    29. [29]

      Huang, E. Q.; Wang, Y.; Yang, N.; Shu, B. W.; Zhang, G. H.; Liu, D. Y. Anal. Bioanal. Chem. 2021, 413 (7), 1787.

    30. [30]

      Mali, L.; Brassard, D.; Fonte, D. D.; Nassif, C.; Mounier, M.; Ponton, A.; Geissler, M.; Shiu, M.; Morton, K. J.; Veres, T. Lab Chip 2022, 22 (17), 3157.

    31. [31]

      Li, F. Y.; Zheng, Y.; Yang, M.; Zhang, Y. W.; Pu, Q. S. Sensor. Actuat. B-Chem. 2022, 351, 130963.

    32. [32]

      Wu, F.; Mao, M.; Cai, L. Y.; Lin, Q.; Guan, X. J.; Shi, X. Y.; Ma, L. ACS Biomater. Sci. Eng. 2022, 8 (9), 3924.

    33. [33]

      Sachdeva, S.; Davis, R. W.; Saha, A. K. Front. Bioeng. Biotechnol. 2021, 8, 602659.

    34. [34]

      Wu, Q. R.; Liu, J. F.; Wang, X. H.; Feng, L. Y.; Wu, J. B.; Zhu, X. L.; Wen, W. J.; Gong, X. Q. BioMed. Eng. Online 2020, 19 (1), 9.

    35. [35]

      Reardon, S. Nature 2015, 523 (7560), 266.

    36. [36]

      Huh, D.; Matthews, B. D.; Mammoto, A.; Montoya-Zavala, M.; Hsin, H. Y.; Ingber, D. E. Science 2010, 328 (5986), 1662.

    37. [37]

    38. [38]

      Nakao, Y.; Kimura, H.; Sakai, Y.; Fujii, T. Biomicrofluidics 2011, 5 (2), 22212.

    39. [39]

      Kimura, H.; Yamamoto, T.; Sakai, H.; Sakai, Y.; Fujii, T. Lab Chip 2008, 8 (5), 741.

    40. [40]

      Kimura, H.; Ikeda, T.; Nakayama, H.; Sakai, Y.; Fujii, T. J. Lab. Auto. 2015, 20 (3), 265.

    41. [41]

      Zheng, L. L.; Wang, B.; Sun, Y. F.; Dai, B.; Fu, Y. F.; Zhang, Y. L.; Wang, Y. W.; Yang, Z. J.; Sun, Z.; Zhuang, S. L.; et al. ACS Sens. 2021, 6 (3), 823.

    42. [42]

      Boken, J.; Soni, S. K.; Kumar, D. Crit. Rev. Anal. Chem. 2016, 46 (6), 538.

    43. [43]

    44. [44]

      Sanjay, S. T.; Zhou, W.; Dou, M.; Tavakoli, H.; Ma, L.; Xu, F.; Li, X. Adv. Drug Deliv. Rev. 2018, 128, 3.

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