Citation: Fengyun Li,  Lei Zhou,  Lin Zhang,  Qiaosheng Pu. Being Precise on Microscale: Exploration on Introducing Microfluidics into Teaching of Analytical Chemistry[J]. University Chemistry, ;2023, 38(9): 89-97. doi: 10.3866/PKU.DXHX202210081 shu

Being Precise on Microscale: Exploration on Introducing Microfluidics into Teaching of Analytical Chemistry

  • Corresponding author: Qiaosheng Pu, puqs@lzu.edu.cn
  • Received Date: 26 October 2022

  • The microfluidics has been widely applied in analytical chemistry and many other fields ascribed to its excellent ability to manipulate fluids on the microscale. The introduction of microfluidics to the undergraduate courses of analytical chemistry will expand the cutting-edge contents, help the teaching process and improve students' learning interest. Herein, we review the history of microfluidics, summarize the ideological and political elements in these contents, briefly introduce the important theories in the area of microfluidics and fabrication processes of microfluidic chips, and discuss their relationship with analytical chemistry. Recent research progresses of the microfluidics in the fields of analytical chemistry research are presented with a focus on bioanalysis. We hope this can be a reference for the introduction of microfluidics into the teaching of analytical chemistry.
  • 加载中
    1. [1]

    2. [2]

    3. [3]

      Nguyen, N. T.; Wereley, S. T. Fundamental and Applications of Microfluidics, 2nd ed.; ArtechHouse:Boston, USA, 2006.

    4. [4]

    5. [5]

      Micheli, A. J.; Thomas, V.; Grillo, F.; Kapur, M.; Schuerle, S. J. Chem. Educ. 2022, 99 (3), 1272.

    6. [6]

    7. [7]

    8. [8]

    9. [9]

    10. [10]

    11. [11]

      Terry, S. C.; Herman, J. H.; Angell, J. B. IEEE Trans. Electron. Dev. 1979, 26 (12), 1880.

    12. [12]

      Manz, A.; Graber, N.; Widmer, H. M. Sensor. Actuat. B-Chem. 1990, 1, 244.

    13. [13]

      Duffy, D. C.; McDonald, J. C.; Schueller, O. J.; Whitesides, G. M. Anal. Chem. 1998, 70, 4974.

    14. [14]

      Thorsen, T.; Maerkl, S. J.; Quake, S. R. Science 2002, 298 (5593), 580.

    15. [15]

      Martinez, A. W.; Phillips, S. T.; Butte, M. J.; Whitesides, G. M. Angew. Chem. Int. Ed. 2007, 46 (8), 1318.

    16. [16]

    17. [17]

      Deshmukh, S. S.; Goswami, A. Mater. Manuf. Process. 2021, 36 (5), 501.

    18. [18]

      Hansen, T. S.; Selmeczi, D.; Larsen, N. B. J. Micromech. Microeng. 2010, 20 (1), 015020.

    19. [19]

    20. [20]

      Reynolds, O. Philos. Trans. R. Soc. London 1883, 174, 935.

    21. [21]

      Shang, L.; Cheng, Y.; Zhao, Y. Chem. Rev. 2017, 117 (12), 7964.

    22. [22]

      Tabelling, P. Introduction to Microfluidics; Oxford Press:Oxford, USA, 2005.

    23. [23]

    24. [24]

      Lin, C. H.; Hsiao, Y. H.; Chang, H. C.; Yeh, C. F.; He, C. K.; Salm, E. M.; Chen, C.; Chiu, I. M.; Hsu, C. H. Lab Chip 2015, 15 (14), 2928.

    25. [25]

      Kim, H. S.; Devarenneb, T. P.; Han, A. Lab Chip 2015, 15 (11), 2467.

    26. [26]

      Huebner, A.; Olguin, L. F.; Bratton, D.; Whyte, G.; Huck, W. T. S.; de Mello, A. J.; Edel, J. B.; Abell, C.; Hollfelder, F. Anal. Chem. 2008, 80, 3890.

    27. [27]

      Baret, J. C.; Miller, O. J.; Taly, V.; Ryckelynck, M.; Harrak, A. E.; Frenz, L.; Rick, C.; Samuels, M. L.; Hutchison, J. B.; Agresti, J. J.; et al. Lab Chip 2009, 9 (13), 1850.

    28. [28]

    29. [29]

      Huang, E. Q.; Wang, Y.; Yang, N.; Shu, B. W.; Zhang, G. H.; Liu, D. Y. Anal. Bioanal. Chem. 2021, 413 (7), 1787.

    30. [30]

      Mali, L.; Brassard, D.; Fonte, D. D.; Nassif, C.; Mounier, M.; Ponton, A.; Geissler, M.; Shiu, M.; Morton, K. J.; Veres, T. Lab Chip 2022, 22 (17), 3157.

    31. [31]

      Li, F. Y.; Zheng, Y.; Yang, M.; Zhang, Y. W.; Pu, Q. S. Sensor. Actuat. B-Chem. 2022, 351, 130963.

    32. [32]

      Wu, F.; Mao, M.; Cai, L. Y.; Lin, Q.; Guan, X. J.; Shi, X. Y.; Ma, L. ACS Biomater. Sci. Eng. 2022, 8 (9), 3924.

    33. [33]

      Sachdeva, S.; Davis, R. W.; Saha, A. K. Front. Bioeng. Biotechnol. 2021, 8, 602659.

    34. [34]

      Wu, Q. R.; Liu, J. F.; Wang, X. H.; Feng, L. Y.; Wu, J. B.; Zhu, X. L.; Wen, W. J.; Gong, X. Q. BioMed. Eng. Online 2020, 19 (1), 9.

    35. [35]

      Reardon, S. Nature 2015, 523 (7560), 266.

    36. [36]

      Huh, D.; Matthews, B. D.; Mammoto, A.; Montoya-Zavala, M.; Hsin, H. Y.; Ingber, D. E. Science 2010, 328 (5986), 1662.

    37. [37]

    38. [38]

      Nakao, Y.; Kimura, H.; Sakai, Y.; Fujii, T. Biomicrofluidics 2011, 5 (2), 22212.

    39. [39]

      Kimura, H.; Yamamoto, T.; Sakai, H.; Sakai, Y.; Fujii, T. Lab Chip 2008, 8 (5), 741.

    40. [40]

      Kimura, H.; Ikeda, T.; Nakayama, H.; Sakai, Y.; Fujii, T. J. Lab. Auto. 2015, 20 (3), 265.

    41. [41]

      Zheng, L. L.; Wang, B.; Sun, Y. F.; Dai, B.; Fu, Y. F.; Zhang, Y. L.; Wang, Y. W.; Yang, Z. J.; Sun, Z.; Zhuang, S. L.; et al. ACS Sens. 2021, 6 (3), 823.

    42. [42]

      Boken, J.; Soni, S. K.; Kumar, D. Crit. Rev. Anal. Chem. 2016, 46 (6), 538.

    43. [43]

    44. [44]

      Sanjay, S. T.; Zhou, W.; Dou, M.; Tavakoli, H.; Ma, L.; Xu, F.; Li, X. Adv. Drug Deliv. Rev. 2018, 128, 3.

  • 加载中
    1. [1]

      Zhening Lou Quanxing Mao Xiaogeng Feng Lei Zhang Xu Xu Yuyang Zhang Xueyan Liu Hongling Kang Dongyang Feng Yongku Li . Practice of Implementing Blended Teaching in Shared Analytical Chemistry Course. University Chemistry, 2024, 39(2): 263-269. doi: 10.3866/PKU.DXHX202308089

    2. [2]

      Zhenli Sun Ning Wang Kexin Lin Qin Dai Yufei Zhou Dandan Cao Yanfeng Dang . Visual Analysis of Hotspots and Development Trends in Analytical Chemistry Education Reform. University Chemistry, 2024, 39(11): 57-64. doi: 10.12461/PKU.DXHX202403095

    3. [3]

      Tian Li Liping Zhang Ling Liu Ruifang Li Longfei Mao Hui Yang . Reform and Practice of Analytical Chemistry Teaching under the Guidance of Course Ideology and Politics. University Chemistry, 2024, 39(6): 189-194. doi: 10.3866/PKU.DXHX202310014

    4. [4]

      Jinghui Zhang Wei Shen Sheng Tang Ru Jia Wei Zhong . Exploration and Reflection on Interdisciplinary Teaching of Analytical Chemistry in the New Era of International Competition. University Chemistry, 2025, 40(7): 1-9. doi: 10.12461/PKU.DXHX202408019

    5. [5]

      Xin Hua Songqin Liu . Research on Teaching Practice of Spectral Analytical Chemistry Based on Thematic Discussion. University Chemistry, 2025, 40(7): 106-111. doi: 10.12461/PKU.DXHX202408043

    6. [6]

      Linghua Chen . 基于双联动“三学”模式的食品专业分析化学教学改革. University Chemistry, 2025, 40(8): 78-91. doi: 10.12461/PKU.DXHX202409095

    7. [7]

      Sha Pan Bairu Yu Jun Li Ling Wu Dan Li Tianji Ma Zhong Cao . 新形势发展驱动的分析化学双语教学改革之浅见. University Chemistry, 2025, 40(8): 338-344. doi: 10.12461/PKU.DXHX202410056

    8. [8]

      Zhixin Zhou Ran Chen Yuanjian Zhang Songqin Liu Yanfei Shen . 分析化学课程本硕一体化的全英文教学改革. University Chemistry, 2025, 40(6): 64-70. doi: 10.12461/PKU.DXHX202407093

    9. [9]

      Juan Hou Chen Zhou Jing Sun . Teaching Design of the Classical Analytical Chemistry Content Based on Logical and Innovative Thinking: A Case Study of the Application of Acid-Base Titration Method. University Chemistry, 2024, 39(4): 221-226. doi: 10.3866/PKU.DXHX202310023

    10. [10]

      Hongwei Ma Fang Zhang Hui Ai Niu Zhang Shaochun Peng Hui Li . Integrated Crystallographic Teaching with X-ray,TEM and STM. University Chemistry, 2024, 39(3): 5-17. doi: 10.3866/PKU.DXHX202308107

    11. [11]

      Yan Zhang Ping Wang Tiebo Xiao Futing Zi Yunlong Chen . Measures for Ideological and Political Construction in Analytical Chemistry Curriculum. University Chemistry, 2024, 39(4): 255-260. doi: 10.3866/PKU.DXHX202401017

    12. [12]

      Fang Li Bo Xiong Hui Xu Wenling Gu Jingming Gong Chengzhou Zhu . Localization, Contemporary Relevance, Future Vision: Edition Evolution of Analytical Chemistry Textbook Co-Edited by Central China Normal University. University Chemistry, 2025, 40(7): 148-155. doi: 10.12461/PKU.DXHX202410068

    13. [13]

      Guangming Yang Yunhui Long . Design and Implementation of Analytical Chemistry Curriculum Based on the Learning Community of Teachers and Students. University Chemistry, 2024, 39(3): 132-137. doi: 10.3866/PKU.DXHX202309089

    14. [14]

      Shuangyan Huan Jianhui Jiang Gongke Li Wenqing Zhang Na Li Yi Yang Bin Hu Yang Tian Shuo Wu Sichun Zhang Yonghai Yue Dechen Jiang Zengping Chen Zhonglin Lu Cheng Cui Yuzhi Wang Weihong Tan . Exploration on the Construction of Analytical Chemistry Core Curriculum in the Chemistry “101 Plan”. University Chemistry, 2024, 39(10): 22-26. doi: 10.12461/PKU.DXHX202409003

    15. [15]

      Yali Yuan Jinfang Nie Jianping Li Wenying Jin Lin Li . 具有鲜明地方和专业特色的分析化学课程思政体系构建. University Chemistry, 2025, 40(8): 18-24. doi: 10.12461/PKU.DXHX202410007

    16. [16]

      Nan Xiao Fang Sun . 二芳基硫醚化合物的构建及应用. University Chemistry, 2025, 40(6): 360-363. doi: 10.12461/PKU.DXHX202407099

    17. [17]

      Tingting Jiang Jing Chang . Application of Ideological and Political Education in Chemical Analysis Experiment under the Background of Emerging Engineering Education: Taking the Redox Titration Experiment as an Example. University Chemistry, 2024, 39(2): 168-174. doi: 10.3866/PKU.DXHX202308007

    18. [18]

      Wen-Bing Hu . Systematic Introduction of Polymer Chain Structures. University Chemistry, 2025, 40(4): 15-19. doi: 10.3866/PKU.DXHX202401014

    19. [19]

      Min Gu Huiwen Xiong Liling Liu Jilie Kong Xueen Fang . Rapid Quantitative Detection of Procalcitonin by Microfluidics: An Instrumental Analytical Chemistry Experiment. University Chemistry, 2024, 39(4): 87-93. doi: 10.3866/PKU.DXHX202310120

    20. [20]

      Liuchuang Zhao Wenbo Chen Leqian Hu . Discussion on Improvement of Teaching Contents about Common Evaluation Parameters in Analytical Chemistry. University Chemistry, 2024, 39(2): 379-391. doi: 10.3866/PKU.DXHX202308079

Metrics
  • PDF Downloads(0)
  • Abstract views(1019)
  • HTML views(43)

通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Address:Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888
Powered By info@rhhz.net

/

DownLoad:  Full-Size Img  PowerPoint
Return