Citation: Xinqi Zhan, Zhaohui Zhou. Chemical Mechanism of Nephrogenic Systemic Fibrosis and Its Inhibition with Double Chelation[J]. University Chemistry, ;2023, 38(12): 86-90. doi: 10.3866/PKU.DXHX202209029 shu

Chemical Mechanism of Nephrogenic Systemic Fibrosis and Its Inhibition with Double Chelation

Xinqi Zhan ^1,, ,
Zhaohui Zhou ^2,3,,

1.
Medical College, Xiamen University, Xiamen 361005, Fujian Province, China;
2.
State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen 361005, Fujian Province, China;
3.
College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian Province, China

Corresponding author: Xinqi Zhan, Zhaohui Zhou,
Received Date: 12 September 2022

A small proportion of nephropathy patients administered gadolinium contrast agents for nuclear magnetic resonance have been reported to develop nephrogenic systemic fibrosis (NSF). This paper introduces the mechanism of the transformation and deposition of NSF, aiming to reveal the chemical nature of the gadolinium phosphate bioparticles in nephrogenic system fibrosis. This research will provide an important theoretical basis for future studies on the occurrence, development, and formation of nephrogenic system fibrosis and the removal of sediment residues. Moreover, a new idea for introducing a biocompatible second chelating agent into the gadolinium contrast agent system has been proposed, which aims to improve the safe use of gadolinium contrast agent.
- Nephrogenic systemic fibrosis,
- Gadolinium contrast agent,
- Chelation,
- Chemical mechanism
1. [1]
2. [2]
3. [3]
4. [4]
  Carr, D. H.; Brown, J.; Bydder, G. M.; Steiner, R. E.; Weinmann, H. J.; Speck, U.; Hall, A. S. I.; Young, R. Am. J. Roentgenol. 1984, 143 (2), 215.
5. [5]
  Weinmann, H. J.; Brasch, R. C.; Press, W. R. Am. J. Roentgenol. 1984, 142 (3), 619.
6. [6]
7. [7]
  Bulte, J. W. M.; Kraitchman, D. L. NMR Biomed. 2004, 17 (7), 484.
8. [8]
  Caravan, P.; Ellison, J. J.; McMurry, T. J.; Lauffer, R. B. Chem. Rev. 1999, 99 (9), 2293.
9. [9]
  Caravan, P. Chem. Soc. Rev. 2006, 35 (6), 512.
10. [10]
  Cowper, S. E.; Robin, H. S.; Steinberg, S. M.; Su, L. D.; Gupta, S.; LeBoit, P. E. Lancet 2000, 356 (9234), 1000.
11. [11]
  Cowper, S. E.; Su, L. D.; Bhawan, J.; Robin, H. S.; LeBoit, P. E. Am. J. Dermatopathol. 2001, 23 (5), 383.
12. [12]
  Grobner, T. Nephrol. Dial. Transplant 2006, 21 (4), 1104.
13. [13]
  Marckmann, P.; Skov, L.; Rossen, K.; Dupont, A.; Damholt, M. B.; Heaf, J.; Thomsen, H. S. J. Am. Soc. Nephrol. 2006, 17 (9), 2359.
14. [14]
  Thomsen, H. S.; Morcos, S. K.; Dawson, P. Clin. Radiol. 2006, 61 (11), 905.
15. [15]
  Murphy, K. J.; Brunberg, J. A.; Cohan, R. H. Am. J. Roentgenol. 1996, 167 (4), 847.
16. [16]
  FDA drug safety communication: New warnings for using gadolinium-based contrast agents in patients with kidney dysfunction. [2023-01-06]. https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-new-warnings-using-gadolinium-based-contrast-agents-patients-kidney
17. [17]
  CDC: Nephrogenic fibrosing dermopathy associated with exposure to gadolinium-containing contrast agents. [2023-01-06]. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5607a1.htm
18. [18]
  MRI questions and answers. International Society for Magnetic Resonance in Medicine.[2023-01-06]. https://www.ismrm.org/
19. [19]
  Wahsner, J.; Gale, E. M.; Rodriguez, R. A.; Caravan, P. Chem. Rev. 2019, 119 (2), 957.
20. [20]
  Boyd, A. S.; Zic, J. A.; Abraham, J. L. J. Am. Acad. Dermatol. 2007, 56 (1), 27.
21. [21]
  Boyd, A. S.; Sanyal, S.; Abraham, J. L. J. Am. Acad. Dermatol. 2010, 62 (2), 337.
22. [22]
  Abraham, J. L.; Thakral, C.; Skov, L.; Rossen, K.; Marckmann, P. Brit. J. Dermatol. 2008, 158 (2), 273.
23. [23]
  George, S. J.; Webb, S. M.; Abraham, J. L.; Cramer, S. P. Brit. J. Dermatol. 2010, 163 (5), 1077.
24. [24]
  Lessing, P. A.; Erickson, A. W. J. Euro. Ceram. Soc. 2003, 23 (16), 3049.
25. [25]
  Gao, S.; George, S.; Zhou, Z. H. Dalton Trans. 2016, 45 (12), 5388.
26. [26]
  Chen, M. L.; Tang, X.; Lu, T. H.; Zhan, X. Q.; Zhou, Z. H. J. Coord. Chem. 2020, 72 (9), 1547.
27. [27]
  Gao, S.; Chen, M. L.; Zhou, Z. H. Dalton Trans. 2014, 43 (2), 639.
28. [28]
  Scott, L. J. Clin. Drug Invest. 2018, 38 (9), 773.
29. [29]
  Ponrartana, S.; Moore, M. M.; Chan, S. S.; Victoria, T.; Dillman, J. R.; Chavhan, G. B. Pediatr. Radiol. 2021, 51 (5), 736.
1. [1]
  Jialin Wu , Zixuan Jiang , Pengfei Zhang , Weiming Xu . Application of the STEAM Education Concept in General Chemistry Courses: Integrating Chemistry, History, and Art through Systematic Protection and Promotion of Cultural Relics. University Chemistry, 2025, 40(11): 382-390. doi: 10.12461/PKU.DXHX202412055
2. [2]
  Ruilan Fan , Xiaoling Huang . 磷源的选择及三种含磷阻燃剂的合成与阻燃性. University Chemistry, 2025, 40(8): 181-191. doi: 10.12461/PKU.DXHX202410025
3. [3]
  Zhenhua Wang , Haoyang Feng , Xiaoyang Shao , Wenru Fan . Vitamins in Solid Propellants: Controlled Synthesis of Neutral Macromolecular Bonding Agents. University Chemistry, 2025, 40(4): 1-9. doi: 10.3866/PKU.DXHX202401007
4. [4]
  Ling Zhang , Jing Kang . Turn Waste into Valuable: Preparation of High-Strength Water-Based Adhesives from Polymethylmethacrylate Wastes: a Comprehensive Chemical Experiments. University Chemistry, 2024, 39(2): 221-226. doi: 10.3866/PKU.DXHX202306075
5. [5]
  Jingxuan Zhang , Weihao Jiang , Siyuan Zhang , Hongye Tian , Ziye Huang , Lin Huang , Qikun Wu , Jing Yang , Yibin Jiang , Cheng Wang . Automation and AI-Assisted Investigation of the Chemical Reactivity of Sulfosalicylic Acid. University Chemistry, 2026, 41(1): 332-345. doi: 10.12461/PKU.DXHX202505108
6. [6]
  Jiabo Huang , Quanxin Li , Zhongyan Cao , Li Dang , Shaofei Ni . Elucidating the Mechanism of Beckmann Rearrangement Reaction Using Quantum Chemical Calculations. University Chemistry, 2025, 40(3): 153-159. doi: 10.12461/PKU.DXHX202405172
7. [7]
  Lingling Li , Zhe Chen . Charge transfer mechanism investigation of S-scheme photocatalyst using soft X-ray absorption spectroscopy. Acta Physico-Chimica Sinica, 2026, 42(4): 100215-0. doi: 10.1016/j.actphy.2025.100215
8. [8]
  Xuan Zhou , Yi Fan , Zhuoqi Jiang , Zhipeng Li , Guowen Yuan , Laiying Zhang , Xu Hou . Liquid Gating Mechanism and Basic Properties Characterization: a New Experimental Design for Interface and Surface Properties in the Chemistry “101 Plan”. University Chemistry, 2024, 39(10): 113-120. doi: 10.12461/PKU.DXHX202407111
9. [9]
  Zhiwen HU , Jiayan ZHOU , Huiying ZHANG , Yulong YANG , Ping LI , Zelong CHEN , Weixia DONG , Qifu BAO . Influence mechanism of stoichiometric ratio on the catalytic performance of Bi₁₂TiO₂₀/BaTiO₃ heterojunction. Chinese Journal of Inorganic Chemistry, 2026, 42(4): 773-788. doi: 10.11862/CJIC.20250251
10. [10]
  Wang Wang , Yucheng Liu , Shengli Chen . Use of NiFe Layered Double Hydroxide as Electrocatalyst in Oxygen Evolution Reaction: Catalytic Mechanisms, Electrode Design, and Durability. Acta Physico-Chimica Sinica, 2024, 40(2): 2303059-0. doi: 10.3866/PKU.WHXB202303059
11. [11]
  Ning CHEN , Jingle CHEN , Hongyuan ZHU , Huali CHEN , Liguang WU , Ting WANG . Mechanism and performance regulation of Co/Zr-doped mesoporous TiO₂ catalysts in activating sodium persulfate for tetracycline degradation. Chinese Journal of Inorganic Chemistry, 2026, 42(3): 507-518. doi: 10.11862/CJIC.20250275
12. [12]
  Lingbang Qiu , Jiangmin Jiang , Libo Wang , Lang Bai , Fei Zhou , Gaoyu Zhou , Quanchao Zhuang , Yanhua Cui . In Situ Electrochemical Impedance Spectroscopy Monitoring of the High-Temperature Double-Discharge Mechanism of Nb₁₂WO₃₃ Cathode Material for Long-Life Thermal Batteries. Acta Physico-Chimica Sinica, 2025, 41(5): 100040-0. doi: 10.1016/j.actphy.2024.100040
13. [13]
  Yonghui Wang , Weilin Chen , Yangguang Li . Knowledge Construction of “Solubility of Inorganic Substances” in Elemental Chemistry Teaching. University Chemistry, 2024, 39(4): 261-267. doi: 10.3866/PKU.DXHX202312102
14. [14]
  Shuang Yang , Qun Wang , Caiqin Miao , Ziqi Geng , Xinran Li , Yang Li , Xiaohong Wu . Ideological and Political Education Design for Research-Oriented Experimental Course of Highly Efficient Hydrogen Production from Water Electrolysis in Aerospace Perspective. University Chemistry, 2024, 39(11): 269-277. doi: 10.12461/PKU.DXHX202403044
15. [15]
  Feifei Yang , Wei Zhou , Chaoran Yang , Tianyu Zhang , Yanqiang Huang . Enhanced Methanol Selectivity in CO₂ Hydrogenation by Decoration of K on MoS₂ Catalyst. Acta Physico-Chimica Sinica, 2024, 40(7): 2308017-0. doi: 10.3866/PKU.WHXB202308017
16. [16]
  Qin′ai FENG , Jianjun LI , Lili ZHANG , Linxin WU , Huiling WANG , Wenjing HOU , Lei WANG , Mingjie REN . Amphiphilic surface modification of magnetic adsorbents and its adsorption properties of two microplastics. Chinese Journal of Inorganic Chemistry, 2026, 42(4): 789-807. doi: 10.11862/CJIC.20250208
17. [17]
  Xiufang Wang , Donglin Zhao , Kehua Zhang , Xiaojie Song . “Preparation of Carbon Nanotube/SnS₂ Photoanode Materials”: A Comprehensive University Chemistry Experiment. University Chemistry, 2024, 39(4): 157-162. doi: 10.3866/PKU.DXHX202308025
18. [18]
  Kai Yang , Gehua Bi , Yong Zhang , Delin Jin , Ziwei Xu , Qian Wang , Lingbao Xing . Comprehensive Polymer Chemistry Experiment Design: Preparation and Characterization of Rigid Polyurethane Foam Materials. University Chemistry, 2024, 39(4): 206-212. doi: 10.3866/PKU.DXHX202308045
19. [19]
  Wenkai Chen , Yunjia Shen , Xiangmeng Kong , Yanli Zeng . Quantum Chemistry Calculation of Key Physical Quantity in Circularly Polarized Luminescence: Introducing an Exploratory Computational Chemistry Experiment. University Chemistry, 2025, 40(3): 83-91. doi: 10.12461/PKU.DXHX202405018
20. [20]
  Dawei Zhang , Yuqian Zhao , Mingyu Jiao , Yan Wang . Cultivation of Students’ Critical Thinking in the Practice of Ideological and Political in Organic Chemistry Courses: Taking the Discrimination and Analysis of Chemical Rumors as Examples. University Chemistry, 2025, 40(4): 181-188. doi: 10.12461/PKU.DXHX202405211

Get Citation

PDF

XML

Metrics

PDF Downloads(3)
Abstract views(1254)
HTML views(142)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142