Citation: Xinqi Zhan, Zhaohui Zhou. Chemical Mechanism of Nephrogenic Systemic Fibrosis and Its Inhibition with Double Chelation[J]. University Chemistry, ;2023, 38(12): 86-90. doi: 10.3866/PKU.DXHX202209029 shu

Chemical Mechanism of Nephrogenic Systemic Fibrosis and Its Inhibition with Double Chelation

Xinqi Zhan ^1,, ,
Zhaohui Zhou ^2,3,,

1.
Medical College, Xiamen University, Xiamen 361005, Fujian Province, China;
2.
State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen 361005, Fujian Province, China;
3.
College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian Province, China

Corresponding author: Xinqi Zhan, Zhaohui Zhou,
Received Date: 12 September 2022

A small proportion of nephropathy patients administered gadolinium contrast agents for nuclear magnetic resonance have been reported to develop nephrogenic systemic fibrosis (NSF). This paper introduces the mechanism of the transformation and deposition of NSF, aiming to reveal the chemical nature of the gadolinium phosphate bioparticles in nephrogenic system fibrosis. This research will provide an important theoretical basis for future studies on the occurrence, development, and formation of nephrogenic system fibrosis and the removal of sediment residues. Moreover, a new idea for introducing a biocompatible second chelating agent into the gadolinium contrast agent system has been proposed, which aims to improve the safe use of gadolinium contrast agent.
- Nephrogenic systemic fibrosis,
- Gadolinium contrast agent,
- Chelation,
- Chemical mechanism
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沈阳化工大学材料科学与工程学院沈阳 110142