Citation: Yanni Su, Yi Lü, Lichun Zhang. Chemiluminescence Immunoassay: A Sharp Tool for in Vitro Diagnosis[J]. University Chemistry, ;2023, 38(1): 141-148. doi: 10.3866/PKU.DXHX202203066 shu

Chemiluminescence Immunoassay: A Sharp Tool for in Vitro Diagnosis

College of Chemistry, Sichuan University, Chengdu 610064, China

Corresponding author: Lichun Zhang, zhanglichun@scu.edu.cn
Received Date: 28 March 2022

Blood, body fluids, and tissue samples from the human body are rich in information. Any disease or condition of the human body can be determined by detecting relevant markers; this method is called “in vitro diagnosis”. Immune diagnosis is a crucial part of in vitro diagnosis. Chemiluminescence immunoassay is one of the mainstream technologies for conducting immune diagnosis. Based on the principle of the specific binding of the antigen antibody, chemiluminescence immunoassay has good specificity and sensitivity in clinical applications as well as in food and environment domains. Herein, several in vitro diagnosis techniques are briefly introduced, with emphasis on the principle, classification, application field, and development trend of chemiluminescence immunoassay.
- diagnosis,
- Immunoassay,
- Chemiluminescence immunoassay,
- Principle,
- Classification,
- Application
1. [1]
2. [2]
3. [3]
  Schurr, F.; Tison, A.; Militano, L.; Cheviron, N.; Sircoulomb, F.; Riviere, M. P.; Ribiere, C. M.; Thiery, R.; Dubois, E. J. Virol. Methods. 2019, 270, 70.
4. [4]
5. [5]
  Yalow, R. S.; Berson, S. A. Nature 1959, 184, 1684.
6. [6]
  Faulk, W. P.; Taylor, G. M. Immunochemistry 1971, 8 (11), 1081.
7. [7]
  Engvall, E.; Perlmann, P. Immunochemistry 1971, 8 (9), 871.
8. [8]
  Halmann, M.; Velan, B.; Sery, T. Appl. Environ. Microbiol. 1977, 34, 473.
9. [9]
10. [10]
11. [11]
12. [12]
  Wang, S. S.; Wang, M. M.; Li, C. P.; Li, H. J.; Ge, C. H.; Zhang, X. D.; Jin, Y. D. Sensors Actuat. B-Chem. 2020, 311, 127919.
13. [13]
  Tang, Y.; Zhang, B. H.; Wang, Y.; Zhao, F. Q.; Zeng, B. Z. ACS Appl. Nano Mater. 2021, 4 (7), 7264.
14. [14]
  Lee, Y.; Kim, S. S.; Lee, J. H. Anal. Chim. Acta 2019, 1060, 8.
15. [15]
  Bao, Y.; Han, K.; Ding, Z.; Li, Y.; Li, T.; Guan, M.; Li, G. Spectrochim. Acta A Mol. Biomol. 2021, 253, 119562.
16. [16]
  Zhang, Z.; Xu, Y.; Ma, B.; Ma, Z.; Han, H. Talanta 2021, 235, 122736.
17. [17]
  Mo, G. C.; Qin, D. M.; Jiang, X. H.; Zheng, X. F.; Mo, W. M.; Deng, B. Y. Sensors Actuat. B-Chem. 2020, 310, 127852.
18. [18]
  Mao, Y.; Wang, N.; Yu, F.; Yu, S.; Liu, L.; Tian, Y.; Wang, J.; Wang, Y.; He, L.; Wu, Y. Analyst 2019, 144 (16), 4813.
19. [19]
  Lin, Y.; Jia, J.; Yang, R.; Chen, D.; Wang, J.; Luo, F.; Guo, L.; Qiu, B.; Lin, Z. Anal. Chem. 2019, 91 (5), 3717.
20. [20]
21. [21]
  Vankrieken, L.; Hertogh, D. R. Clin. Chem. 1995, 41 (1), 36.
22. [22]
  Souter, I.; Bellavia, A.; Williams, P. L.; Korevaar, T. I. M.; Meeker, J. D.; Braun, J. M.; De Poortere, R. A.; Broeren, M. A.; Ford, J. B.; Calafat, A. M.; et al. Environ. Health Perspect. 2020, 128 (6), 67007.
23. [23]
  Zhao, K.; Tang, M.; Wang, H.; Zhou, Z.; Wu, Y.; Liu, S. Biosens. Bioelectron. 2019, 126, 767.
24. [24]
  Flehmig, B.; Ranke, M.; Berthold, H.; Gerth, J. H. J. Infect. Dis. 1979, 140 (2), 169.
25. [25]
26. [26]
27. [27]
28. [28]
  Huang, Z. J.; Han, W. D.; Wu, Y. H.; Hu, X. G.; Yuan, Y. N.; Chen, W.; Peng, H. P.; Liu, A. L.; Lin, X. H. J. Electroanal. Chem. 2017, 785, 8.
29. [29]
  Zong, C.; Wu, J.; Wang, C.; Ju, H. X.; Yan, F. C. Anal. Chem. 2012, 84 (5), 2410.
30. [30]
  Gang, W.; Wan, Y.; Lin, G. F.; Li, Z. X.; Dong, Z. N.; Liu, T. C. J. Immunol. 2020, 484, 112829.
31. [31]
  Li, L. F.; Lin, D.; Yang, F.; Xiao, Y. Y.; Yang, L.; Yu, S. M.; Jiang, C. L. ACS Appl. Nano Mater. 2021, 4 (4), 3932.
32. [32]
  Shu, Q.; Wang, L.; Ouyang, H.; Wang, W.; Liu, F.; Fu, Z. Biosens. Bioelectron. 2017, 87, 908.
33. [33]
  Roth-Konforti, M.; Green, O.; Hupfeld, M.; Fieseler, L.; Heinrich, N.; Ihssen, J.; Vorberg, R.; Wick, L.; Spitz, U.; Shabat, D. Angew. Chem. Int. Ed. 2019, 58 (30), 10361.
34. [34]
  Yang, R.; Liu, J.; Song, D.; Zhu, A.; Xu, W.; Wang, H.; Long, F. Mikrochim. Acta 2019, 186 (11), 726.
35. [35]
  Wan, W. W.; Ouyang, H. Anal. Chem. 2019, 149, 104055.
36. [36]
  Liu, Z. J.; Xu, Y.; Xu, X. Y.; Wang, M. H. Analyst 2013, 138, 3280.
37. [37]
  Juachon, M. J.; Regala, J. G.; Marquez, J.; Bailon, M. X. Open Chem. 2019, 17, 270.
38. [38]
  Pang, Y. Q.; Cui, H.; Zheng, H. S.; Wan, G. H.; Liu, L. J.; Yu, X. F. Luminescence 2005, 20 (1), 8.
39. [39]
40. [40]
  Osamu, N.; Ji, X. Y.; Larry, J. K. J. Biolumin. Chemilumin. 1995, 10, 151.
41. [41]
  Li, N.; Liu, D. Q.; Cui, H. Anal. Bioanal. Chem. 2014, 406, 5561.
42. [42]
  Li, H. F.; Zhao, M.; Liu, W.; Chu, W. R.; Guo, Y. M. Talanta 2016, 147 (15), 430.
43. [43]
  He, Y.; Xu, B.; Li, W. H.; Yu, H. L. J. Agric. Food Chem. 2015, 63 (11), 2930.
44. [44]
  Huang, Y.; Gao, L.; Cui, H. ACS Appl. Mater. Interfaces 2018, 10 (20), 17040.
45. [45]
  Rasoulzadeh, F.; Amjadi, M. J. Photochem. 2021, 420, 113493.
46. [46]
  Ouyang, H.; Wang, L. M.; Yang, S. J.; Wang, W. W.; Wang, L.; Liu, F. Q.; Fu, Z. F. Anal. Chem. 2015, 87 (5), 2952.
47. [47]
  Broeke, L. J. P.; Bruijn, V. G.; Heijnen, J. H. M.; Keurentjes. J. T. F. Ind. Eng. Chem. Res. 2001, 40, 5240.
48. [48]
  Zhang, B.; Liu, W.; Liu, Z.; Fu, X.; Du, D. J. Aoac. Int. 2022, 105 (2), 346.
49. [49]
  Rebeccani, S.; Wetzl, C.; Zamolo, V. A.; Criado, A.; Valenti, G.; Paolucci, F.; Prato, M. Chem. Commun. 2021, 57 (76), 9672.
50. [50]
  Jie, M.; Yu, S.; Yu, F.; Liu, L.; He, L.; Li, Y.; Zhang, H.; Qu, L.; Harrington, P. B.; Wu, Y. J. Sci. Food Agric. 2018, 98 (9), 3384.
51. [51]
  Fu, Z, F.; Yang, Z. J.; Tang, J. H.; Liu, H.; Feng, Y.; Ju, H. X. Anal. Chem. 2007, 79, 7376.
52. [52]
53. [53]
  Hu, B. F.; Li, J. J.; Mou, L.; Liu, Y.; Deng, J. Q.; Qian, W.; Sun, J. S.; Cha, R. T.; Jiang, X. Y. Lab Chip 2017, 17, 2225.
54. [54]
  Li, Q.; Zhang, L.; Li, J.; Lu, C. Trends Analyt. Chem. 2011, 30 (2), 401.
55. [55]
  Gao, H. F.; Han, J.; Yang, S. J.; Wang, Z. X.; Wang, L.; Fu, Z. F. Anal. Chim. Acta 2014, 839, 91.
56. [56]
  Gómez, V.; Callao, M. P. Trends Analyt. Chem. 2007, 26 (8), 767.
57. [57]
58. [58]
59. [59]
60. [60]
61. [61]
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