Citation: Xiangqing Feng,  Haifeng Du. 2021年度诺贝尔化学奖:大道至简[J]. University Chemistry, ;2022, 37(1): 211201. doi: 10.3866/PKU.DXHX202112014 shu

2021年度诺贝尔化学奖:大道至简

  • 有机小分子成为继酶和金属催化剂之后发展的一类新型催化剂,被称为第三类催化。有机小分子催化作为一种精确的分子构建新工具,对手性新药研发产生了巨大影响,在药物、农药、化工、材料等领域都得到了广泛的应用。2021年的诺贝尔化学奖授予了德国化学家本杰明·利斯特和美国化学家大卫·迈克米伦,以表彰他们在这一领域做出的开创性重要贡献。本文简述了手性现象和不对称催化,有机小分子催化的发展历程及其催化优势和未来前景。
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    1. [1]

      Kagan, H. B. In Comprehensive Asymmetric Catalysis; Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H. Eds.; Springer-Verlag:Berlin, Heidelberg, Germany, 1999.

    2. [2]

      Yang, X.-H.; Xie, J.-H.; Zhou, Q.-L. Org. Chem. Front. 2014, 1, 190.

    3. [3]

      Bredig, G.; Fiske, P. S. Biochemische Zeitschrift 1913, 46, 7.

    4. [4]

      Eder, U.; Sauer, G.; Weichert, R. Angew. Chem. Int. Ed. 1971, 10, 496.

    5. [5]

      Hajos, Z. G.; Parrish, D. R. J. Org. Chem. 1974, 39, 1615.

    6. [6]

      Yang, D.; Yip, Y.-C.; Tang, M.-W.; Wong, M.-K.; Zheng, J.-H.; Cheung, K.-K. J. Am. Chem. Soc. 1996, 118, 491.

    7. [7]

      Yang, D. Acc. Chem. Res. 2004, 37, 497.

    8. [8]

      Tu, Y.; Wang, Z.-X.; Shi, Y. J. Am. Chem. Soc. 1996, 118, 9806.

    9. [9]

      Shi, Y. Acc. Chem. Res. 2004, 37, 488.

    10. [10]

      Zhu, Y.; Wang, Q.; Cornwall, R. G.; Shi, Y. Chem. Rev. 2014, 114, 8199.

    11. [11]

      Feng, X.; Du, H. Chin. J. Chem. 2021, 39, 2016.

    12. [12]

      List, B.; Lerner, R. A.; Barbas, C. F. J. Am. Chem. Soc. 2000, 122, 2395.

    13. [13]

      List, B. Acc. Chem. Res. 2004, 37, 548.

    14. [14]

      Ahrendt, K. A.; Borths, C. J.; MacMillan, D. W. C. J. Am. Chem. Soc. 2000, 122, 4243.

    15. [15]

      Ouellet, S. G.; Walji, A. M.; MacMillan, D. W. C. Acc. Chem. Res. 2007, 40, 1327.

    16. [16]

      James, T.; van Gemmeren, M.; List, B. Chem. Rev. 2015, 115, 9388.

    17. [17]

      Beeson, T. D.; Mastracchio, A.; Hong, J.-B.; Ashton, K.; MacMillan, D. W. C. Science 2007, 316, 582.

  • 加载中
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