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Citation: Sheng Li, Shuang Yang, Yonghao Liu, Zizhuo Zhao, Qi Zhang, Zhiyan Huang. 绿色催化氧化合成邻硝基苯甲醛——一个氧化合成教学实验[J]. University Chemistry, ;2022, 37(5): 211108. doi: 10.3866/PKU.DXHX202111088 shu

绿色催化氧化合成邻硝基苯甲醛——一个氧化合成教学实验

School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China

Corresponding author: Zhiyan Huang, zyhuang@snnu.edu.cn
Received Date: 30 November 2021

采用“科学问题为目标导向”的实验教学指导原则，将邻硝基苯甲醛的绿色合成工艺开发为有机化学基础实验，丰富了绿色氧化反应在实验教学中的应用。本新创实验以水溶性2-（2，2，6，6-四甲基-4-亚哌啶基-1-氧化物）乙酸（简称TEMPO-COOH）为催化剂，在摩尔分数0.1%用量下，催化次氯酸钠氧化邻硝基苄醇，实现了重要有机合成中间体邻硝基苯甲醛的高选择性绿色催化合成，产率达93%，纯度>99%。作为本科生基础教学实验，本案例不仅涉及多种有机化学实验基本操作，还包含反应监测、结构表征、纯度分析等重要环节，同时还融入了绿色化学理念和有机合成方法学研究的实验探究过程。该新创实验所用试剂环境友好，安全性高，教学时长约为3-4 h，非常适合用于有机化学基础实验教学。以本实验方案为蓝本，结合有关氧化反应研究进展的微课学习和拓展练习，实现了理论知识与合成实践之间的有效互动，提升了化学专业本科生解决较为复杂有机合成问题的综合能力，提高了化学类人才的培养质量。
- Green chemistry,
- 2-Nitrobenzaldehyde,
- TEMPO-COOH,
- NaClO,
- Catalytic oxidation
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