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Citation: Shaoling Cheng, Huan Zhang, Hongxiang Xie, Cong Han. 乙酰水杨酸制备实验副产物分析[J]. University Chemistry, ;2022, 37(7): 211007. doi: 10.3866/PKU.DXHX202110076 shu

乙酰水杨酸制备实验副产物分析

College of Science, Tianjin University of Science & Technology, Tianjin 300457, China

Corresponding author: Cong Han, hanc@tust.edu.cn
Received Date: 25 October 2021

乙酰水杨酸的制备是许多高校有机化学实验开设的经典项目之一，教材及文献普遍认为副产物是水杨酸的聚合物。本文按经典制备方法，收集了副产物，进行了薄层色谱、红外光谱、核磁共振和熔点测定鉴定结构，确定副产物是乙酰水杨酸酐，不含有水杨酸的聚合物。探讨了乙酰水杨酸酐产生的原因，为乙酰水杨酸制备实验教学中知识传授的准确性提供了科学依据，有利于培养学生敢于质疑和勇于创新的精神，以及教学质量的提高。
- Salicylic acid,
- Acetylsalicylic acid,
- Acetylsalicylic anhydride,
- Aspirin
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
  Nishi, I. Acetylsalicylic Anhydride. JPN. 41021607[P]. 1966-12-17.
13. [13]
  Rakesh, K. P.; Sean, M.; Joshua, H. C.; Trenton, B. B.; Shanta, D. Angew. Chem. Int. Ed. 2014, 53, 1963.
14. [14]
15. [15]
1. [1]
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2. [2]
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3. [3]
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4. [4]
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5. [5]
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6. [6]
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7. [7]
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8. [8]
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9. [9]
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12. [12]
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13. [13]
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15. [15]
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16. [16]
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17. [17]
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18. [18]
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19. [19]
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