Citation: Zhi Xue, Xianzhi Dai, Lie Yu, Zisong Yang, Yiyan Hong, Youqi Pu, Yan Zhou, Fei Huang. Pd/C催化Suzuki反应合成4-联苯甲酸[J]. University Chemistry, ;2022, 37(5): 211004. doi: 10.3866/PKU.DXHX202110046 shu

Pd/C催化Suzuki反应合成4-联苯甲酸

Zhi Xue ^1,, ,
Xianzhi Dai ¹ ,
Lie Yu ¹ ,
Zisong Yang ¹ ,
Yiyan Hong ¹ ,
Youqi Pu ¹ ,
Yan Zhou ¹ ,
Fei Huang ²

1.
College of Resources & Environment, Aba Teachers University, Wenchuan 623002, Sichuan Province, China;
2.
School of Resource and Environmental Engineering, Yibin University, Yibin 644000, Sichuan Province, China

Corresponding author: Zhi Xue, chemxz@163.com
Received Date: 15 October 2021

通过芳基卤代物和芳基硼酸合成联苯类化合物的Suzuki-Miyaura偶联反应被广泛应用于天然产物，药物和功能材料的合成。然而目前本科教学中极少有相关实验，主要是由于传统的Suzuki反应条件通常需要昂贵的含配体Pd催化剂，反应溶剂大多含有诸如甲苯或者1，4-二氧六环等有毒害溶剂，反应过程需要惰性气体氛围，且大多需在加热反应8 h以上。这些限制极大地阻碍了本科生开展这一重要的有机化学实验。本文介绍了改进的Suzuki反应条件：无配体Pd/C作为催化剂，乙醇和水的混合溶剂作为反应溶剂，并且室温搅拌半小时反应即可结束，反应全程敞口需要空气（氧气）的辅助而不是惰性氛围。在此条件下，以苯硼酸与4-溴苯甲酸为原料，碳酸钾作为碱，高效合成了4-联苯甲酸。相比传统Suzuki反应条件下催化剂均为一次性使用，不可回收，本实验中回收的Pd/C催化剂可循环使用5次以上而几无活性损失。本实验项目从成本，可操作性，绿色环保等角度为本科生熟悉Suzuki反应提供了可能。
- 4-Bibenzoic acid,
- Suzuki-Miyaura reaction,
- Pd/C,
- Air atmosphere,
- Recycle and reuse
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