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Citation: Zhonghua Xi, Dadong Lu, Jie Dai, Tao Ye, Wenwei Zhang. 核磁共振技术测定联萘酚的对映体纯度[J]. University Chemistry, ;2022, 37(2): 210902. doi: 10.3866/PKU.DXHX202109027 shu

核磁共振技术测定联萘酚的对映体纯度

National Demonstration Center for Experimental Chemistry Education(Nanjing University), Nanjing 210023, China

Corresponding author: Zhonghua Xi, xizh@nju.edu.cn
Received Date: 10 September 2021

手性联萘酚（（±）-BINOL）制备是国内高校常开设的一个实验，其产品的对映体纯度测试是实验的重要一环。以2-甲酰基苯硼酸和（S）-（-）-1-苯乙胺的混合物作为手性试剂与联萘酚发生Bull-James Assembly反应，以此设计了核磁共振氢谱（¹H NMR）测定联萘酚对映体纯度的实验。实验结果表明，通过反应生成的对映体混合物的核磁信号，能准确地计算出（±）-BINOL的对映体纯度。以选定的苯环氢核信号计算出的（R）-BINOL含量与理论ee值有着良好的线性关系（R²=0.9999）。此实验方法能够快速完成大量学生样品的测量，同时大大减少实验废液的产生量。学生通过此实验可对核磁共振技术有更进一步的了解。
- Nuclear magnetic resonance (NMR),
- Binaphthol (BINOL),
- Enantiomeric purity,
- Enantiomeric excess
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