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Citation: Wenquan Wang, Meng Liu, Kang Sun, Zhifeng Liu, Xiaohui Ji, Quan Liu. 基于流动化学平台的3-(2-羟基苯基)-1-(吡啶-3-基)丙-2-烯-1-酮合成实验改进[J]. University Chemistry, ;2022, 37(7): 210902. doi: 10.3866/PKU.DXHX202109021 shu

基于流动化学平台的3-(2-羟基苯基)-1-(吡啶-3-基)丙-2-烯-1-酮合成实验改进

College of Chemical Environment Science, Shaanxi University of Technology, Hanzhong 723000, Shaanxi Province, China

Corresponding author: Quan Liu, liuq@snut.edu.cn
Received Date: 6 September 2021

流动化学技术相较于传统间歇式反应，具有高传热与传质效率、高反应安全性、短反应时间以及可精准控制反应参数等优点，从而成为有机合成中最具潜力的技术之一。国外多所高校已经开设流动化学相关课程实验，而我国相关课程实验仍处于起步阶段。本实验将传统有机实验中Claisen-Schmidt反应合成查尔酮衍生物进行改进，通过搭建液相-液相流动化学反应平台进行流动化学合成，并通过紫外-可见光谱仪对反应过程进行监测。该实验在实现相同教学目的下，具有反应时间短、现象明显、碱用量少等显著优势。
- Flow Chemistry,
- Claisen-Schmidt reaction,
- Chalcone derivative,
- Synthesis
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