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Citation: Mengshi Jin, Jiabin Shen, Jun Xu, Pengfei Zhang, Wanmei Li. 喹喔啉酮类JNK3抗肿瘤抑制剂的绿色合成——推荐一个综合化学实验[J]. University Chemistry, ;2022, 37(1): 210403. doi: 10.3866/PKU.DXHX202104034 shu

喹喔啉酮类JNK3抗肿瘤抑制剂的绿色合成——推荐一个综合化学实验

Experimental Chemistry Teaching Center of Zhejiang Province, College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China

Corresponding author: Wanmei Li, liwanmei@hznu.edu.cn
Received Date: 13 April 2021

介绍一个涵盖有机合成、药物化学与仪器分析等学科的研究探索型综合实验，本实验选择具有抗癌、抗菌、抗糖尿病和抗病毒活性的喹喔啉酮类烯胺酮分子作为合成与研究对象，首次使用可循环的酸性树脂Amberlyst 15为非均相催化剂，在可见光的协同催化下，利用Mannich反应一步合成喹喔啉酮类JNK3（c-Jun N-terminal kinase 3）抑制剂。本实验取材于学科前沿热点且已有较多验证的研究前沿成果，不仅有助于学生可以学习到经典Mannich反应的实验操作方法，巩固了专业知识的理解，同时也紧跟时事，学习非均相催化和光催化的相关知识，结合拓展阅读，提高了他们的探索创新意识。建议纳入本科高年级和研究生低年级的“综合化学实验”课程。
- Mannich reaction,
- Enaminones,
- Quinoxalin-2(1H)-one,
- Photocatalysis,
- Heterogeneous catalysis
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