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Citation: Liqi Li, Xiaorong Yang, Yuan Zhang. 可见光诱导的2,2-二(1H-吲哚-3-基)乙酸乙酯的合成——推荐一个绿色有机化学实验[J]. University Chemistry, ;2021, 36(4): 200501. doi: 10.3866/PKU.DXHX202005019 shu

可见光诱导的2,2-二(1H-吲哚-3-基)乙酸乙酯的合成——推荐一个绿色有机化学实验

College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

Corresponding author: Yuan Zhang, zhangyuan@lzu.edu.cn
Received Date: 7 May 2020

可见光催化由于其清洁、高效、反应条件温和等优点，近年来已在有机合成领域得到广泛应用。但是目前可见光催化的反应尚未在本科生实验教学中得以推广。3，3'-二吲哚基甲烷骨架广泛存在于药物分子结构中，其也可以作为生物碱类天然产物合成的重要中间体。最近，我们发展了一种通过可见光诱导的甘氨酸衍生物与吲哚间的需氧脱氢偶联反应来合成3，3'-二吲哚基甲烷的方法。在此工作的基础上，我们设计了一个以N-（4-甲氧基苯基）甘氨酸乙酯和吲哚为原料，以罗丹明6G为光催化剂，在可见光照射、室温条件下高效合成2，2-二（1H-吲哚-3-基）乙酸乙酯的半微量绿色有机化学实验，目的在于通过将前沿科研内容引入实验教学，进一步促使大学生开拓知识视野、树立“绿色化学”理念和环保意识。
- Photoredox catalysis,
- Ethyl 2,2-di(1H-indol-3-yl) acetate,
- Green chemistry,
- Undergraduate laboratory teaching
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