Citation: Ming Zhao, Liqing Yang, Yurong Xu. 氮杂环卡宾催化的亲核取代反应[J]. University Chemistry, ;2021, 36(4): 200404. doi: 10.3866/PKU.DXHX202004042 shu

氮杂环卡宾催化的亲核取代反应

Department of Chemistry and Chemical Engineering, Hefei Normal University, Hefei 230601, China

Corresponding author: Ming Zhao, zhaomnwu@126.com
Received Date: 9 April 2020

氮杂环卡宾作为有机催化剂催化的反应取得了巨大的研究进展；在反应中，氮杂环卡宾可以改变醛类化合物的反应极性，由亲电性转变为亲核性。本文主要对氮杂环卡宾催化的亲核取代反应进行了详细介绍，极性反转的醛可以通过S_N1、S_N2、S_N2'、加成-消去、消去-加成过程和相应的底物发生反应。对于醛作为亲核试剂发生的取代反应，能够丰富和完善基础教学中醛酮反应知识点的内容，有利于学生了解学科的前沿发展，激发学生的探索和学习兴趣。
- N-Heterocyclic carbene,
- Organocatalysis,
- Nucleophilic substitution,
- Aldehyde
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