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Citation: ZHANG Hui. Past and Present of Nimodipine as Hypotensor[J]. University Chemistry, ;2018, 33(7): 43-55. doi: 10.3866/PKU.DXHX201803060 shu

Past and Present of Nimodipine as Hypotensor

ZHANG Hui

College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian Province, P. R. China

Received Date: 28 March 2018
Revised Date: 8 April 2018

Following the discovery and application of 1,4-dihydropyridines nimodipine as the antihypertensive drug, this article briefly reviews the development of stereochemistry in Europe since the middle of the 19th century. Chemical stories are introduced, involving the invention of Hantzsch esters, close relationship between Hantzsch and his outstanding student-the founder of Coordination Chemistry-Werner, and Werner's pioneering contribution to chiral stereochemistry. An up-to-date introduction is given for the spontaneous resolution of racemic nimodipine under chiral crystallization and its precise characterization. Moreover, polymorphism and polymorphic drugs have been also described.
- Chiral stereochemistry,
- Hantzsch reaction,
- Hypotensor,
- Polymorphism,
- Spontaneous resolution
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