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Citation: LI Zhifei, GAO Ning. Cryo-EM Method for High-Resolution Structure Determination: A Brief Introduction to 2017 Nobel Prize in Chemistry[J]. University Chemistry, ;2018, 33(1): 1-6. doi: 10.3866/PKU.DXHX201711035 shu

Cryo-EM Method for High-Resolution Structure Determination: A Brief Introduction to 2017 Nobel Prize in Chemistry

LI Zhifei ,
GAO Ning

State Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, P. R. China

Received Date: 28 November 2017

The 2017 Nobel Prize in chemistry was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for their contribution to developing the cryo-electron microscopy (cryo-EM) method for high-resolution structure determination of biomolecules in solution. In recent years, cryo-EM is leading a revolution in structural biology, and becoming a major tool in studying the structure and function of biomolecular machines. Here, we briefly describe the method development of cryo-EM and the personal contributions of the three Nobel Laureates.
- Cryo-electron microscopy,
- Biomolecules,
- Structural biology,
- Nobel Prize in chemistry
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