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Citation: WANG Zhipeng A., CHENG Nongyi, LI Man, WANG Tian. Applying Bioorthogonal Reactions to the Synthesis of Proteins Containing Lysine Post-Translational Modification Mimics[J]. University Chemistry, ;2018, 33(3): 48-54. doi: 10.3866/PKU.DXHX201709018 shu

Applying Bioorthogonal Reactions to the Synthesis of Proteins Containing Lysine Post-Translational Modification Mimics

WANG Zhipeng A. ^1,2, ,
CHENG Nongyi ⁴ ,
LI Man ^1,3 ,
WANG Tian ⁵

1.
Department of Chemistry, Texas A & M University, College Station, Texas 77840, USA;
2.
Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China;
3.
Department of Plant Pathology and Microbiology, Texas A & M University, College Station, Texas 77840, USA;
4.
Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA 53706;
5.
Division of Biological Science, University of California, San Diego, La Jolla 92093, USA

Received Date: 12 September 2017

As an important topic in epigenetic research, post-translational modifications (PTMs) have been drawing more and more attention recently. With the increasing number of novel PTMs discovered, they have been found widely existing in human proteome. Although cell biology research showed their significant roles in the regulation of chromatin structure and gene transcription functions, the more detailed functions are remaining unclear. For further biology research, chemical biologists need to develop synthetic strategies for the proteins with specific PTMs at desired sites. This manuscript will introduce the application of bioorthogonal reactions to protein chemistry for the incorporation of lysine PTMs. We hope it can contribute to the research and education ongoing.
- Post-translational modification,
- Bioorthogonal reaction,
- Proteome
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