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Citation: CHEN Tian-Yang, ZHANG Wen-Xiong. Transition-Metal-Catalyzed Cleavage of Amide C-N Bonds[J]. University Chemistry, ;2017, 32(6): 1-12. doi: 10.3866/PKU.DXHX201702018 shu

Transition-Metal-Catalyzed Cleavage of Amide C-N Bonds

College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China

Transition-metal-catalyzed cleavage of amide C-N bonds has become one of the hot fields of organic chemistry and organometallic chemistry. The cleavage of amide carbonyl C-N bonds catalyzed by transition-metal catalysts can be mainly classified into five pathways: i) via oxidative addition, ii) via acyl migration in ammonium species, iii) via protonolysis, iv) via hydrogenation, and v) via decarboxylation. Transition-metal-catalyzed cleavage of amide non-carbonyl C-N bonds can be divided into four classes: i) via oxidative addition, ii) via nucleophilic attack, iii) via imine or iminium species, and iv) via β-amino elimination. This review briefly summarized the different modes of transition-metal-catalyzed cleavage of amide carbonyl and non-carbonyl C-N bonds in recent years.
- Amides,
- Cleavage of C-N bonds,
- Transition-metal catalysis
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