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Citation: LIU Jin, WEI Kun, CAI Le, CAO Qiu-E, LIU Shi-Xi. Improved Synthesis of Benzocaine: A Proposal for an Environmentally Friendly Oxidation Method as the Key Step[J]. University Chemistry, ;2016, 31(3): 64-67. doi: 10.3866/PKU.DXHX20160364 shu

Improved Synthesis of Benzocaine: A Proposal for an Environmentally Friendly Oxidation Method as the Key Step

1.
School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China

Corresponding author: LIU Jin,
Fund Project: 云南省质量工程教改项目(X311308) (X311308)

An improved synthesis of benzocaine is described. The synthetic route developed involves trichloroisocyanuric acid and 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO) co-oxidation system as the key step. The method could avoid high toxicity, pollution, post-processing difficulties and other unfavorable environmental factors. The reactions were carried out under room temperature for short time with high yield and safe, easy, and environment-friendly operation.
- Green chemistry,
- Benzocaine,
- Oxidation,
- Trichloroisocyanuric acid,
- TEMPO
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