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Citation: WANG Cuijie, GAO Yu, LI Xinglin, ZHAO Wuduo, YU Ajuan, ZHANG Shusheng. Synthesis of a chiral metal-organic framework using zinc oxide as zinc source for enantioselective adsorption of 2,2'-furoin racemate[J]. Chinese Journal of Chromatography, ;2020, 38(5): 516-521. doi: 10.3724/SP.J.1123.2019.10024 shu

Synthesis of a chiral metal-organic framework using zinc oxide as zinc source for enantioselective adsorption of 2,2'-furoin racemate

WANG Cuijie ¹ ,
GAO Yu ¹ ,
LI Xinglin ¹ ,
ZHAO Wuduo ² ,
YU Ajuan ^1,, ,
ZHANG Shusheng ^1,2,,

1.
College of Chemistry, Zhengzhou University, Zhengzhou 450001, China;
2.
The Center of Advanced Analysis and Gene Sequencing, Zhengzhou 450001, China

Corresponding author: YU Ajuan, ZHANG Shusheng,
Received Date: 24 October 2019

Fund Project: National Natural Science Foundation of China (Nos. 21675144, 21775140, 21705143).

Chiral metal-organic frameworks (CMOFs),[Zn(L-mal)(H₂O)₂]_n were prepared by using zinc oxide instead of the traditional metal inorganic salt as the zinc source, and their chiral separation performance was investigated. Equal amounts of ZnO and L-malic acid were dissolved in H₂O, and[Zn(L-mal)(H₂O)₂]_n were obtained by allowing the mixture to stand at room temperature for 24 h. Then, 100 mg[Zn(L-mal)(H₂O)₂]_n as the adsorbent was added to 250 μL 1 g/L 2,2'-furoin racemate, and 4.5 mL isopropanol and 1 mL methanol were selected as the extraction solvent and elution solvent, respectively, for selective adsorption experiments. The final filtrate was analyzed by high performance liquid chromatography (HPLC). The results showed that[Zn(L-mal)(H₂O)₂]_n exhibited better selective adsorption ability for R-2,2'-furoin with 20% enantiomeric excess (ee). This work provides a new method for the green preparation of CMOF and expands its application in the field of chiral separation.
- chiral separation,
- chiral metal-organic frameworks (CMOF),
- zinc oxide,
- 2,2'-furoin racemate
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