Citation: XIA Hongjun, LIU Jiawei, BAI Quan. Research progress on core-shell silica stationary phases for high performance liquid chromatography[J]. Chinese Journal of Chromatography, ;2020, 38(4): 372-382. doi: 10.3724/SP.J.1123.2019.08014 shu

Research progress on core-shell silica stationary phases for high performance liquid chromatography

XIA Hongjun ^1,2 ,
LIU Jiawei ¹ ,
BAI Quan ^1,,

1.
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Institute of Modern Separation Science, Key Lab of Modern Separation Science in Shaanxi Province, Northwest University, Xi'an 710069, China;
2.
Henan Key Laboratory of Rare Earth Functional Materials, Zhoukou Normal University, Zhoukou 466000, China

Corresponding author: BAI Quan, baiquan@nwu.edu.cn
Received Date: 19 August 2019

Fund Project: National Natural Science Foundation of China (Nos. 21874106, 21545007, 21605122)

Fast and efficient separation by using high performance liquid chromatography (HPLC) is challenging for a wide range of samples. In recent years, core-shell silica microspheres have been widely investigated and used for highly efficient and fast separation under reasonably low pressure for small solutes, biopolymers, and complex samples. In this paper, the mechanism for fast separation and preparation methods of core-shell silica microspheres are introduced, along with their application for HPLC-based separation of small molecules, peptides, and biological macromolecules in HPLC. The developing trends of using core-shell microspheres in HPLC are also presented.
- core-shell silica microspheres,
- high performance liquid chromatography (HPLC),
- fast separation and analysis,
- review
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