基于色谱-质谱联用的脂质分析样品前处理技术研究进展

杨吉娜 刘丹阳 周婷

引用本文: 杨吉娜,  刘丹阳,  周婷. 基于色谱-质谱联用的脂质分析样品前处理技术研究进展[J]. 色谱, 2020, 38(1): 74-85. doi: 10.3724/SP.J.1123.2019.06023 shu
Citation:  YANG Jina,  LIU Danyang,  ZHOU Ting. Recent advances in sample preparation techniques for the lipid profiling based on chromatography-mass spectrometry[J]. Chinese Journal of Chromatography, 2020, 38(1): 74-85. doi: 10.3724/SP.J.1123.2019.06023 shu

基于色谱-质谱联用的脂质分析样品前处理技术研究进展

  • 基金项目:

    Fundamental Research Funds for the Central Universities (No. 2018MS55).

    Supported by National Natural Science Foundation of China (No. 21775047)

    Pearl River S&T Nova Program of Guangzhou, China (No. 201806010055)

摘要: 脂质作为细胞膜和亚细胞膜的主要结构成分,在能量来源、细胞信号传导等多种生物学过程中发挥着重要作用。近年来,脂质分析受到越来越多的关注,其中色谱-质谱联用技术在脂质分析中占据主导地位。由于样品基质复杂,样品前处理有富集痕量物质和减少基质干扰的作用,成为脂质分析中的一个关键步骤。该文综述了近年来基于色谱-质谱联用技术的脂质分析中样品前处理技术的研究进展和应用,对各种样品前处理技术进行了阐述和总结。基于液相的萃取方法有液-液萃取和单一有机溶剂萃取。基于固相的萃取方法包括固相萃取和固相微萃取。场辅助萃取方法包括超临界流体萃取、加压流体萃取、微波辅助萃取和超声辅助萃取。此外,还介绍了在线联用样品前处理方法和用于活体分析的样品前处理方法。最后,对基于色谱-质谱联用的脂质分析样品前处理技术存在的问题及发展趋势进行了探讨。样品前处理技术的发展将提高脂质分析的灵敏度、选择性和分析速度。

English

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  • 收稿日期:  2019-06-25
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