Citation: ZHOU Hang, CHEN Jia, ZHANG Yingshan, ZHAO Liang, QIU Hongdeng. Preparation and application of quinine-functionalized poly(1-vinylimidazole)-modified silica stationary phase in hydrophilic interaction chromatography[J]. Chinese Journal of Chromatography, ;2020, 38(4): 438-444. doi: 10.3724/SP.J.1123.2019.06008 shu

Preparation and application of quinine-functionalized poly(1-vinylimidazole)-modified silica stationary phase in hydrophilic interaction chromatography

ZHOU Hang ^1,2 ,
CHEN Jia ^1,2 ,
ZHANG Yingshan ³ ,
ZHAO Liang ¹ ,
QIU Hongdeng ^1,,

1.
CAS Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China;
3.
Gansu Province Traditional Chinese Medicine Modern Pharmaceutical Engineering Research Institute, Lanzhou 730000, China

Corresponding author: QIU Hongdeng, hdqiu@licp.cas.cn
Received Date: 14 June 2019

Fund Project: National Natural Science Foundation of China (No. 21822407).

A quinine-functionalized poly(1-vinylimidazole)-modified hydrophilic silica stationary phase (Sil-PIm-Qn) was prepared by surface radical chain transfer and nucleophilic substitution reactions. Sil-PIm-Qn was characterized by elemental analysis and FT-IR. The chromatographic characteristics of the stationary phase were investigated in the hydrophilic interaction chromatographic (HILIC) mode. The results showed that five amino acids, nine sulfonamides, and ten nucleosides/nucleobases could be successfully separated on this stationary phase, respectively. The retention behavior of the compounds on the column was evaluated under different chromatographic conditions, i. e., for different salt concentrations and acetonitrile contents in the mobile phases. The stability of this column was also investigated, and the relative standard deviation (RSD, n=10) of the retention time of Sil-PIm-Qn was 0.08%-2.30%. Given its simple and green preparation as well as its unique selectivity and high separation efficiency, Sil-PIm-Qn is expected to find widespread application in the separation of hydrophilic compounds, including sulfonamides and nucleosides/nucleobases, in real samples.
- hydrophilic interaction chromatography (HILIC),
- chromatographic stationary phase,
- preparation,
- quinine,
- poly(1-vinylimidazole),
- hydrophilic compounds
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