基于微流控驱动和控制技术的临床生化分析系统研究进展

引用本文: 袁颖欣, 樊晨, 潘建章, 方群. 基于微流控驱动和控制技术的临床生化分析系统研究进展[J]. 色谱, 2020, 38(2): 183-194. doi: 10.3724/SP.J.1123.2019.05006 shu

Citation: YUAN Yingxin, FAN Chen, PAN Jianzhang, FANG Qun. Research advances in clinical biochemical analysis systems based on microfluidic driving and control technique[J]. Chinese Journal of Chromatography, 2020, 38(2): 183-194. doi: 10.3724/SP.J.1123.2019.05006 shu

基于微流控驱动和控制技术的临床生化分析系统研究进展

浙江大学化学系微分析系统研究所, 浙江杭州 310058
基金项目:
国家自然科学基金（21435004，21227007）；中央高校基本科研业务费专项资金资助（2019QNA3011）.

摘要: 微流控技术具有微量、高效、高通量、微型化、集成化、自动化的特点，为实现现场化、低成本的临床生化分析提供了一条可行的技术途径。针对于目前临床生化分析中复杂流体操控的难点，该文依据系统中采用驱动和控制方式的不同，对各种基于微流控技术的临床生化分析系统进行了分类介绍，同时也介绍了市场上商品化的微流控生化分析仪器，并对其各自特点进行了综合评述。

关键词:

English

Research advances in clinical biochemical analysis systems based on microfluidic driving and control technique

Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310058, China
Received Date: 06 May 2019
Fund Project:
National Natural Science Foundation of China (Nos. 21435004, 21227007)

Abstract: Microfluidic techniques have the features of high throughput, low consumption, as well as ease of miniaturization, integration, and automation, thus emerging as a feasible solution to cost-effective clinical biochemical analysis. Various clinical biochemical analysis systems based on the microfluidic technique, with different driving and control methods, are introduced in this article, in addition to commercially available microfluidic biochemical analysis instruments. The characteristics of these systems are comprehensively reviewed.

Key words:

1. [1] Manz A, Graber N, Widmer H M. Sens Actuators B, 1990, 1(1/6):244
2. [2] Xiao Z L, Zhang B. Chinese Journal of Chromatography, 2011, 29(10):949 肖志良, 张博. 色谱, 2011, 29(10):949
3. [3] Dungchai W, Chailapakul O, Henry C S. Anal Chim Acta, 2010, 674(2):227
4. [4] Wang W, Wu W Y, Wang W, et al. J Chromatogr A, 2010, 1217(24):3896
5. [5] Zhu W J, Feng D Q, Chen M, et al. Sens Actuators B, 2014, 190:414
6. [6] Suh Y K, Kang S. Micromachines, 2010, 1(3):82
7. [7] Agiotis L, Theodorakos I, Samothrakitis S, et al. J Magn Magn Mater, 2016, 401:956
8. [8] Shields Iv C W, Wang J L, Ohiri K A, et al. Lab Chip, 2016, 16(19):3833
9. [9] Jeon J, Lee J B, Chung S K, et al. Lab Chip, 2016, 17(1):128
10. [10] Luchette P, Abiy N, Mao H. Sens Actuator B, 2007, 128(1):154
11. [11] Barani A, Paktinat H, Janmaleki M, et al. Biosens Bioelectron, 2016, 85:714
12. [12] Collins D J, Ma Z, Ai Y. Anal Chem, 2016, 88(10):5513
13. [13] Van Den Berg A, Craighead H G, Yang P. Chem Soc Rev, 2010, 39(3):899
14. [14] Focke M, Stumpf F, Faltin B, et al. Lab Chip, 2010, 10(19):2519
15. [15] Miao B, Peng N, Li L, et al. Sensors, 2015, 15(11):27954
16. [16] Wang K, Liang R, Chen H, et al. Sens Actuator B, 2017, 251:242
17. [17] Noroozi Z, Kido H, Peytavi R, et al. Rev Sci Instrum, 2011, 82(6):064303
18. [18] Nwankire C E, Donohoe G G, Zhang X, et al. Anal Chim Acta, 2013, 781:54
19. [19] Kim S, Kim D, Kim S. Biosens Bioelectron, 2019, 126:200
20. [20] Badr I H A, Johnson R D, Madou M J, et al. Anal Chem, 2002, 74(21):5569
21. [21] Watts A S, Urbas A A, Moschou E, et al. Anal Chem, 2007, 79(21):8046
22. [22] Duford D A, Xi Y, Salin E D. Anal Chem, 2013, 85(16):7834
23. [23] Nwankire C E, Venkatanarayanan A, Glennon T, et al. Biosens Bioelectron, 2015, 68:382
24. [24] Lee A, Park J, Lim M, et al. Anal Chem, 2014, 86(22):11349
25. [25] Burger R, Kurzbuch D, Gorkin R, et al. Lab Chip, 2015, 15(2):378
26. [26] Duffy D C, Gillis H L, Lin J, et al. Anal Chem, 1999, 71(20):4669
27. [27] Steigert J, Brenner T, Grumann M, et al. Biomed Microdevices, 2007, 9(5):675
28. [28] Nwankire C E, Czugala M, Burger R, et al. Biosens Bioelectron, 2014, 56:352
29. [29] Kuo J N, Chen X F. Microsyst Technol, 2015, 21(11):2485
30. [30] Pollack M G, Fair R B, Shenderov A D. Appl Phys Lett, 2000, 77(11):1725
31. [31] Moon H, Wheeler A R, Garrell R L, et al. Lab Chip, 2006, 6(9):1213
32. [32] Paik P, Pamula V K, Pollack M G, et al. Lab Chip, 2003, 3(1):28
33. [33] Pollack M G, Shenderov A D, Fair R B. Lab Chip, 2002, 2(2):96
34. [34] Sista R S, Eckhardt A E, Srinivasan V, et al. Lab Chip, 2008, 8(12):2188
35. [35] Srinivasan V, Pamula V K, Fair R B. Lab Chip, 2004, 4(4):310
36. [36] Sista R, Hua Z, Thwar P, et al. Lab Chip, 2008, 8(12):2091
37. [37] Mousa N A, Jebrail M J, Yang H, et al. Sci Transl Med, 2009, 1(1):1ra2
38. [38] Mei N, Seale B, Ng A H C, et al. Anal Chem, 2014, 86(16):8466
39. [39] Unger M A, Chou H P, Thorsen T, et al. Science, 2000, 288(5463):113
40. [40] Kartalov E P, Zhong J F, Scherer A, et al. Biotechniques, 2006, 40(1):85
41. [41] Yao B, He Q H, Du W B, et al. Chinese Journal of Chromatography, 2009, 27(5):662 姚波, 何巧红, 杜文斌, 等. 色谱, 2009, 27(5):662
42. [42] Munyan J W, Fuentes H V, Draper M, et al. Lab Chip, 2003, 3(4):217
43. [43] Suzuki H, Yoneyama R. Sens Actuator B, 2003, 96(1/2):38
44. [44] Do J, Lee S, Han J, et al. Lab Chip, 2008, 8(12):2113
45. [45] Zhu Y, Zhang Y X, Cai L F, et al. Anal Chem, 2013, 85(14):6723
46. [46] Yuan Y X.[MS Dissertation]. Hangzhou:Zhejiang University, 2013 袁颖欣.[硕士学位论文]. 杭州:浙江大学, 2013
47. [47] Müller R H, Clegg D L. Anal Chem, 1949, 21(9):1123
48. [48] Liana D D, Raguse B, Gooding J J, et al. Sensors, 2012, 12(9):11505
49. [49] Cate D M, Adkins J A, Mettakoonpitak J, et al. Anal Chem, 2014, 87(1):19
50. [50] Nery E W, Kubota L T. Anal Bioanal Chem, 2013, 405(24):7573
51. [51] Jiang Y, Ma C C, Hu X Q, et al. Progress in Chemistry. 2014, 26(1):167 蒋艳, 马翠翠, 胡贤巧, 等. 化学进展, 2014, 26(1):167
52. [52] Qi Y L, Ding Y S. Modern Instruments & Medical Treatment, 2013, 19(3):7 齐云龙, 丁永胜. 现代仪器与医疗, 2013, 19(3):7
53. [53] Martinez A W, Phillips S T, Butte M J, et al. Angew Chem Int Ed, 2007, 46(8):1318
54. [54] Martinez A W, Phillips S T, Carrilho E, et al. Anal Chem, 2008, 80(10):3699
55. [55] Dungchai W, Chailapakul O, Henry C S. Anal Chem, 2009, 81(14):5821
56. [56] Lu Y, Shi W, Jiang L, et al. Electrophoresis, 2009, 30(9):1497
57. [57] Martinez A W, Phillips S T, Whitesides G M, et al. Anal Chem, 2010, 82(1):3
58. [58] Cardoso T M G, Garcia P T, Coltro W K T. Anal Methods, 2015, 7(17):7311
59. [59] Liu H, Crooks R M. Anal Chem, 2012, 84(5):2528
60. [60] Criel M, Jonckheere S, Langlois M. Clin Lab, 2016, 62(3):285
61. [61] Schot M J C, van Delft S, Kooijman-Buiting A M J, et al. BMJ Open, 2015, 5(5):e006857
62. [62] Surchi H, Rea R. Practical Diabetes, 2017, 34(1):28

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基于微流控驱动和控制技术的临床生化分析系统研究进展

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Research advances in clinical biochemical analysis systems based on microfluidic driving and control technique

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