Citation: XU Dunming, LAI Guoyin, CHEN Yan, LUO Chao, YI Xionghai, DENG Xiaojun, FENG Feng, ZHANG Feng. Simultaneous determination of 21 illegally added compounds in health foods by ultra high performance liquid chromatography-tandem mass spectrometry with solid phase extraction[J]. Chinese Journal of Chromatography, ;2019, 37(7): 778-785. doi: 10.3724/SP.J.1123.2019.01016 shu

Simultaneous determination of 21 illegally added compounds in health foods by ultra high performance liquid chromatography-tandem mass spectrometry with solid phase extraction

XU Dunming ^1, ,
LAI Guoyin ¹ ,
CHEN Yan ¹ ,
LUO Chao ¹ ,
YI Xionghai ² ,
DENG Xiaojun ² ,
FENG Feng ³ ,
ZHANG Feng ³

1.
Technical Center of Xiamen Customs, Xiamen 361026, China;
2.
Technical Center for Animal Plant and Food Inspection and Quarantine, Shanghai Customs, Shanghai 200135, China;
3.
Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100123, China

Received Date: 21 January 2019

Fund Project: National Key Research and Development Program of China (Nos. 2017YFC1601606, 2017YFF0211003)

A rapid method for the simultaneous determination of 21 illegally added compounds in health foods was developed based on solid phase extraction (SPE) combined with ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). After ultrasonic extraction with acetonitrile, the samples were purified on an HLB SPE column, separated on a Waters BEH C18 column (100 mm×2.1 mm, 1.7 μm) using 10 mmol/L ammonium acetate aqueous solution and methanol as the mobile phases. The compounds were detected by an electrospray ionization (ESI) source in positive ion mode with multi-reaction monitoring (MRM). The 21 illegal additives showed good linear relationships with correlation coefficients no less than 0.995. The limits of detection (LODs) were 3-160 μg/kg for different matrixes. The recoveries ranged from 61.8% to 109.3%, and the relative standard deviations ranged from 1.6% to 14.7%. The method can be used for the simultaneous determination of the illegally added drugs in the losing weight, lipid-lowering, anti-diabetic and anti-hypertension health foods.
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