Citation: ZHANG Mengting, GONG Dandan, SUN Wanyang, SUN Guoxiang. Separation of alkaloids using radial chromatography and its separation efficiency[J]. Chinese Journal of Chromatography, ;2018, 36(10): 1045-1052. doi: 10.3724/SP.J.1123.2018.05016 shu

Separation of alkaloids using radial chromatography and its separation efficiency

1.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;
2.
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China

Received Date: 14 May 2018

Fund Project: National Natural Science Foundation of China (Nos. 90612002, 81573586).

The radial thin layer chromatography (RTLC) is a chromatographic method for the simple, rapid and efficient separation of samples from the center along the radial direction. Simple device was assembled to separate the alkaloids contented in Zhusha Anshen Pills (ZSASP). Based on the theory of thin layer chromatography, the test was designed to compare the separation efficiency of radial chromatography and general thin layer chromatography. The RTLC is faster, more efficient, more economical, and more suitable for the separation of high polar samples like alkaloids as proved. The theoretical root of the high separation efficiency of radial thin layer method was explored, which also provided new methods and ideas for theoretical innovation.
- plane chromatography,
- radial thin layer chromatography (RTLC),
- alkaloids,
- separation efficiency,
- test design verification,
- data fitting
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1.
沈阳化工大学材料科学与工程学院沈阳 110142