Citation: QIN Ling, DONG Yalei, WANG Gangli, CAO Jin, DING Hong. Determination of 42 veterinary drug residues in common animal derived food by dispersive solid phase extraction coupled with liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2018, 36(9): 880-888. doi: 10.3724/SP.J.1123.2018.04024 shu

Determination of 42 veterinary drug residues in common animal derived food by dispersive solid phase extraction coupled with liquid chromatography-tandem mass spectrometry

National Institutes for Food and Drug Control, Beijing 100050, China

Received Date: 23 April 2018

A liquid chromatography-tandem mass spectrometry method, coupled with a dispersive solid phase extraction (DSPE) procedure for sample preparation, was developed to determine 13 classes of 42 veterinary drugs in four representative animal-derived foods. The analytes were dispersed with water, extracted with acetonitrile containing 5% (v/v) formic acid, salted out by salts, and purified by DSPE. The analytes were separated on a C18 column (100 mm×2.1 mm, 2 μ m) with gradient elution using the mobile phase containing methanol and 0.1% (v/v) formic acid aqueous solution. Electrospray ionization-mass spectrometry was performed in multiple reaction monitoring mode for analysis of the 42 compounds. The correlation coefficients of the standard calibration curves for the 42 veterinary drugs were all above 0.995. Most recoveries at three spiked levels in the four representative matrixes ranged from 65.8% to 135.5%, with relative standard deviations of 0.5%-14.2% (n=6). The limits of detection (LODs, S/N=3) and the limits of quantification (LOQs, S/N=10) were 0.01-1.68 μ g/kg and 0.01-5.62 μ g/kg, respectively. The method is simple, rapid, sensitive, and suitable for the simultaneous determination of the 42 veterinary drugs in animal-derived food.
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