Citation: YAN Mengmeng, CHEN Meng, MENG Xianshuang, GUO Xiangyu, BAI Hua, MA Qiang, WANG Penglong, LEI Haimin. Determination of migration of perfluorooctanoic acid and perfluorooctane sulfonic acid from food contact materials by ionic liquid-based dispersive liquid-liquid microextraction and ultra-performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2018, 36(8): 738-744. doi: 10.3724/SP.J.1123.2018.03039 shu

Determination of migration of perfluorooctanoic acid and perfluorooctane sulfonic acid from food contact materials by ionic liquid-based dispersive liquid-liquid microextraction and ultra-performance liquid chromatography-tandem mass spectrometry

YAN Mengmeng ^1,2, ,
CHEN Meng ^1,2 ,
MENG Xianshuang ¹ ,
GUO Xiangyu ¹ ,
BAI Hua ¹ ,
MA Qiang ¹ ,
WANG Penglong ² ,
LEI Haimin ²

1.
Chinese Academy of Inspection and Quarantine, Beijing 100176, China;
2.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China

Received Date: 31 March 2018

Fund Project: National Key Research & Development Program of China (No.2016YFF0203701).

A new method was developed to determine the migration of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) from food contact materials (FCMs) using ionic liquid-based dispersive liquid-liquid microextraction (IL-DLLME) coupled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). FCM samples were soaked in three food simulants of water, 10% (v/v) aqueous ethanol solution, and 4% (v/v) acetic acid solution for the migration test, and then the migration liquid was extracted and enriched using the IL-DLLME. The key parameters in terms of the type and volume of extractant, vortex time, NaCl concentration, and the speed and time of centrifugation were investigated. The analytes were separated on a Waters ACQUITY UPLC BEH Shield RP18 column (50 mm×2.1 mm, 1.7 μm), eluted by gradient with acetonitrile and water, and quantified by electrospray ionization mass spectrometry in negative mode using multiple reaction monitoring (MRM). The experimental results showed good linearities (r²>0.99) in their concentration ranges. The limits of detection (LODs) were 0.5 and 1 μg/L, and the limits of quantitation (LOQs) were 2 and 5 μg/L for PFOA and PFOS, respectively. The recoveries of PFOA and PFOS ranged from 86.4% to 116.9% at three spiked levels with the relative standard deviations (RSDs) between 4.3% and 14.4% (n=6). The proposed method was demonstrated as accurate, efficient, eco-friendly, and suitable for the determination of the migration of PFOA and PFOS from FCMs.
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沈阳化工大学材料科学与工程学院沈阳 110142